Prof. Carlo Pappone

Director of Department of Arrhythmology and Electrophysiology - IRCCS Policlinico San Donato
Professor of Cardiology - Università Vita e Salute San Raffaele
“Since the early years of my profession, I have dealt with sudden death because I was studying Wolff-Parkinson White Syndrome. We imagine our heart as having an electrical system similar to that of a house: this plant must be intact and distribute the current in the rooms of this house, called cardiac chambers. In Wolff-Parkinson White syndrome there are more electric wires than expected: these anomalous wires can conflict with the normal conduction system of the heart, creating a short circuit that causes malignant arrhythmias”
Carlo Pappone

Dr. Pappone’ s research is clinically relevant focusing on, but not limited to, the development of new therapeutic strategies in patients with atrial fibrillation, congestive heart failure, WPW syndrome, and Brugada syndrome.

Atrial fibrillation. His earlier work established a fundamental role of catheter ablation in the treatment of patients with atrial fibrillation “the Pappone’ approach”, representing the seminal strategy that is now accepted as a proven therapeutic tool worldwide. Subsequently, he identified the rotors as responsible for the persistence of atrial fibrillation in patients with persistent chronic atrial fibrillation as target for RF ablation, thereby elucidating the anatomo-functional basis of this complex caotic arrhythmia.

Heart Failure. Another area of research Dr Pappone is currently investigating is the use of cardiac resynchronization therapy by multipoint catheters among patients with refractory heart failure.

WPW syndrome. Dr Pappone first demonstrated that asymptomatic patients with WPW at risk of sudden death can be identified, and that their risk is mediated by well-defined ectrophysiological proprierties of the accessory pathways. These results have impelled a reassessment of current guidelines recommendations and have paved the way fto definitively treat by catheter ablation all asymptomatic patients with accessory pathways at risk of sudden death.

Brugada syndrome. Dr Pappone has recently identified and characterized for the first time the arrhythmic substrate in patients with Brugada syndrome and its treatment by epicardial substrate ablation.

Prof. Carlo Pappone



+ 39 02 5277 – 4260



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“We treat cardiac arrhythmias from genetic studies
to transcatheter ablation“