Ricerca e sviluppo page Archivi

Il Dipartimento di Aritmologia e Elettrofisiologia del Policlinico San Donato è impegnato in modo particolare sulle seguenti linee di ricerca:

Studi clinici e sviluppo di tecnologie e cateteri innovativi per il mappaggio e l’ablazione transcatetere delle seguenti aritmie:
- Fibrillazione atriale (FA)
- Aritmie sopraventricolari, in particolari associate a vie anomale
- Substrato aritmogeno della sindrome di Brugada
- Aritmie ventricolari maligne

Studi clinici e sviluppo di nuovi cateteri e nuove strategie di stimolazione e resincronizzzaione cardiaca (MPP & CCM)
Studi genetico-molecolari sulle principali cardiopatie aritmogene, in particolare per la sindrome di Brugada e la sindrome del QT lungo:
- Correlazione genotipo-fenotipo
- Studi funzionali delle mutazioni osservate
- Approocio omico per la ricerca di nuovi biomarker nelle cardiopatie aritmogene
- Predisposizione aritmica in alcune frequenti sindrome genetiche (Neurofibromatosi di tipo 1, sindrome di Marfan, sindrome di Noonan e sindrome di Ehlers Danlos).
- Sviluppo di terapie geniche

Sviluppo di nuove tecnologie ed analisi elettrocardiografiche per lo studio e la diagnosi delle aritmie cardiache.
- Nuovi modelli di rappresentazione spaziale dei segnali ECG
- Potenziali tardivi (Late potential signal averaging analysi)
- Monitoraggio ECG lungo termine
- Studio dell’apnea del sonno e aritmie

Sviluppo e utilizzo di nuovi sistemi e strategie di telecardiologia
- Monitoraggio remoto dei dispositivi cardiaci impiantabili
- Trasmissione di segnali elettrocardiografici.

L’Istituto di Cardiologia Molecolare e Traslazionale (IMTC) ha come obiettivo principale quello di diventare nei prossimi anni un hub di riferimento per la ricerca e la diagnostica delle malattie cardiovascolari.

Grazie agli strumenti di ultima generazione presenti nel centro, IMTC si pone diversi obiettivi di ricerca tra i quali:

Lo studio della fisiologia e delle patologie cellulari con i più aggiornati sistemi tecnologici e conoscenze all’avanguardia
Lo sviluppo di tecniche di “precision medicine” per la valutazione degli effetti, dell’efficacia e della sicurezza di innovativi trattamenti farmacologici
La caratterizzazione biochimica, molecolare ed elettrofisiologica di difetti genetici responsabili sia delle più frequenti cardiopatie congenite, che delle più rare forme sindromiche coinvolgenti l’apparato cardiovascolare
Lo sviluppo di nuovi test diagnostici per le patologie cardiovascolari mediante l’impiego dell’intelligenza artificiale e di tecniche multiomiche
Lo screening di massa per la diagnosi di pazienti ad alto rischio di morte improvvisa o di cardiomiopatia

Per poter sviluppare tali ricerche, IMTC è costituito da un team multidisciplinare composto da diversi sottogruppi altamente specializzati che comprendono cardiologi, genetisti, biochimici, elettrofisiologi cellulari, chimici esperti in analisi del segnale, ingegneri, matematici e bioinformatici.

Di seguito un elenco dei principali laboratori:

Laboratorio di Biochimica e Analisi Multiomiche
Laboratorio di Biologia Strutturale
Laboratorio di Elettrofisiologia Cellulare
Laboratorio di Medical Devices Development
Laboratorio di Genetica Clinica
Laboratorio di Bioinformatica e Genetica dei Sistemi Complessi
Laboratorio di Intelligenza Artificiale e Analisi dei Segnali

In IMTC verranno quindi svolti dai diversi gruppi di ricerca numerosi esperimenti che spazieranno dalla biologia di base, biologia molecolare, biologia strutturale, elettrofisiologia ed infine alla chimica.

Tutta le attività verranno svolte in conformità con i protocolli di sicurezza e qualità internazionali, in locali attentamente studiati per poter permettere una corretta e sicura sperimentazione.

Il professor Carlo Pappone ha presentato domanda di brevetto per proteggere le seguenti invenzioni. Questo elenco include domande di brevetto che sono già state concesse dall’Ufficio brevetti e marchi degli Stati Uniti (USPTO).

Our Patents

Carlo Pappone has filed for patents to protect the following inventions. This list includes patent applications that have already been granted by the United States Patent and Trademark Office (USPTO).

Ablation catheter with flexible electrode

Patent number: 10188459

Abstract: A flexible tip electrode for an ablation catheter is disclosed. The catheter includes a catheter body and a hollow elongate tip electrode disposed at a distal end of the catheter body. The electrode includes a sidewall provided with one or more elongate gaps extending therethrough. The one or more elongate gaps providing flexibility in the sidewall for bending movement of the tip electrode relative to a longitudinal axis of the catheter body.

Type: Grant
Filed: November 10, 2016
Date of Patent: January 29, 2019
Assignee: St. Jude Medical, Atrial Fibrillation Division, Inc.
Inventors: Carlo Pappone, Alan de la Rama, Peter C. Chen, Cary Hata, Jared A. Shimizu

Analyzing and Mapping ECG signals and determining ablation points to eliminate Brugada Syndrome

Publication number: 20180206750

Abstract: A system and method for Brugada syndrome epicardial ablation comprising preparing an endocardial duration map; preparing a baseline epicardial duration map comprising at least one or more areas of delimination; and when some of the areas of delimination are greater than 200 ms, performing epicardial ablation of the areas of delimination greater than 200 ms. The method may further comprise preparing an updated epicardial duration map after performing epicardial ablation, and determining whether or not a BrS pattern appears in the updated epicardial duration map; and when the BrS pattern appears, performing epicardial ablation. The method may further comprise preparing an updated epicardial duration map after performing epicardial ablation, and determining whether or not an abnormal EGM exists in the updated epicardial duration map; and when the abnormal EGM exists, performing epicardial ablation.

Type: Application
Filed: December 26, 2017
Publication date: July 26, 2018
Applicant: Biosense Webster (Israel) Ltd.
Inventors: Carlo Pappone, Aharon Turgeman, Paolo Roberto Pozzi, Andrea Natalizia

Method ans System for eliminating a broad range of cardiac conditions by analyzing intracardiac signals providing a detailed map and determining potential ablation points

Publication number: 20180206920

Abstract: A system and method for improving ablation procedures is presented. The method may comprise measuring EGM signals; performing three dimensional mapping of the EGM signals; and detecting a location for ablation based on the mapping. The method may further comprise creating a potential duration map, a local activation time map, and a bipolar voltage map. The method may further comprise creating a PDM by defining a window of interest (WOI) comprising at least a cycle length: calculationg previous heart beats based on the cycle length and reference annotation; and assigning the heart beats within the cycle length of the WOI to the WOI
Typr: Application
Filed: December 26, 2017>
Pubblication date: July 26, 2018
Applicant: Biosense Webster (Israel) Ltd.
Inventors: Carlo Pappone, Ahron Turgeman, Paolo Roberto Pozzi, Andrea Natalizia

Thermal Mapping Catheter

Pubblication: 20180042667

Abstract: A catheter is disclosed comprising a catheter shaft including a proximal end and a distal end. A flexible framework can be connected to the distal end of the catheter shaft, wherein the flexible framework includes a plurality of heating electrodes and a temperature sensor. The plurality of heating electrodes can be configured to be heated to a first temperature, the first temperature being lower than which radio frequency ablation is performed. The plurality of heating electrodes can be configured to be heated to a second temperature, the second temperature being a temperature at which radio frequency ablation is performed.

Type: Application
Filed: January 28, 2016
Publication date: February 15, 2018
Inventors: Carlo Pappone, Alan de la Rama, Gabriele Giuseppe Vicedomini, Cary Hata, Tho Hoang Nguyen, Peter Chen

Irrigated catheter with improved fluid flow

Patent number: 9962224

Abstract: An irrigated catheter with uniform cooling and/or uniform fluid distribution in longitudinally spaced apart elution holes by varying the diameter of a fluid delivery lumen. A number of elution holes are provided in a tip region of a catheter body, and these elution holes are in fluid communication with the lumen through ducts. The fluid delivery lumen may be provided with a flow constrictor to restrict flow of fluid towards the distal region.

Type: Grant
Filed: December 23, 2016
Date of Patent: May 8, 2018
Assignee: St. Jude Medical, Atrial Fibrillation Division, Inc.
Inventors: Carlo Pappone, Alan de la Rama, Peter Chen, Cary Hata

Methods and systems for identifying and mapping cardiac activation wavefronts

Patent number: 9888860

Abstract: A map of cardiac activation wavefronts can be created from a plurality of mesh nodes, each of which is assigned a conduction velocity vector. Directed edges are defined to interconnect the mesh nodes, and weights are assigned to the directed edges, thereby creating a weighted directed conduction velocity graph. A user can select one or more points within the weighted directed conduction velocity graph (which do not necessarilycorrespond to nodes), and one more cardiac activation wavefronts passing through these points can be identified using the weighted directed conduction velocity graph. The cardiac activation wavefronts can then be displayed on a graphical representation of the cardiac geometry.

Type: Grant
Filed: August 31, 2006
Date of Patent: February 13, 2018
Assignee: St. Jude Medical, Cardiology Division, Inc.
Inventors: Dongfeng Han, Valtino X. Afonso, Chin-Ann Yang, Dennis J. Morgan, Carlo Pappone

Irrigated flexible ablation catheter

Patent number: 9510903

Abstract: A flexible tip electrode for an ablation catheter is disclosed. The catheter includes a catheter body and a hollow elongate tip electrode disposed at a distal end of the catheter body. The electrode includes a sidewall provided with one or more elongate gaps extending therethrough. The one or more elongate gaps providing flexibility in the sidewall for bending movement of the tip electrode relative to a longitudinal axis of the catheter body.

Type: Grant
Filed: June 24, 2014
Date of Patent: December 6, 2016
Assignee: St. Jude Medical, Atrial Fibrillation Division, Inc.
Inventors: Carlo Pappone, Alan de la Rama, Peter C. Chen, Cary Hata, Jared A. Shimizu

Methods and systems for generationg integrated substrate maps for cardiac arrhythmias

Patent number: 9788751

Abstract: An electrophysiology map, for example a map of arrhythmic substrate, can be generated by acquiring both geometry information and electrophysiology information pertaining to an anatomical region, and associating the acquired geometry and electrophysiology information as a plurality of electrophysiology data points. A user can select two (or more) electrophysiological characteristics for display, and can further elect to apply various filters to the selected electrophysiological characteristics. The user can also define various relationships (e.g., Boolean ANDS, ORs, and the like) between the selected and/or filtered characteristics. The user-selected filtering criteria can be applied to the electrophysiology data points to output various subsets thereof. These subsets can then be graphically rendered using various combinations of colorscale, monochrome scale, and iconography, for example as a three-dimensional cardiac electrophysiology model.

Type: Application
Filed: August 18, 2017
Publication date: February 1, 2018
Inventors: Wenwen Li, Erhan Erdemir, Valtino X. Afonso, Carlo Pappone, Dennis Morgan

Methods and systems for mapping local conduction velocity

Patent number: 9872653

Abstract: The local conduction velocity of a cardiac activation wavefront can be computed by collecting a plurality of electrophysiology (“EP”) data points using a multi-electrode catheter, with each EP data point including both position data and local activation time (“LAT”) data. For any EP data point, a neighborhood of EP data points, including the selected EP data point and at least two additional EP data points, can be defined. Planes of position and LATs can then be defined using the positions and LATs, respectively, of the EP data points within the neighborhood. A conduction velocity can be computed from an intersection of the planes of positions and LATs. The resultant plurality of conduction velocities can be output as a graphical representation (e.g., an electrophysiology map), for example by displaying vector icons arranged in a uniform grid over a three-dimensional cardiac model.

Type: Grant
Filed: October 15, 2015
Date of Patent: October 25, 2016
Assignee: St. Jude Medical, Cardiology Division, Inc.
Inventors: Wenwen Li, Erhan Erdemir, Eric Voth, Valtino Afonso, Carlo Pappone

Magnetically guided catheter with flexible tip

Patent number: 8827910

Abstract: A catheter includes a flexible tubing having a proximal end and a distal end. The catheter also includes an electrode assembly attached to the distal end of the flexible tubing and including a first magnet therein. The electrode assembly including an electrically conductive tip electrode and an electrically nonconductive coupler which is connected between the tip electrode and the distal end of the flexible tubing. The electrically conductive tip electrode comprises a hollow elongated tip electrode including a sidewall provided with one or more elongated gaps extending through the sidewall. The one or more elongated gaps providing flexibility in the sidewall for bending movement of the tip electrode relative to a longitudinal axis of the catheter body. The first magnet is responsive to an external magnetic field to selectively position and guide the electrode assembly within a body of a patient.

Type: Grant
Filed: July 3, 2008
Date of Patent: September 9, 2014
Assignee: St. Jude Medical, Atrial Fibrillation Divsion, Inc.
Inventors: Alan de la Rama, Carlo Pappone, Peter Cheng Chen, Cary Hata, Jared A. Shimizu

Ablation catheter with flexible tip

Patent number: 8790341

Abstract: A flexible tip electrode for an ablation catheter is disclosed. The catheter includes a catheter body and a hollow elongate tip electrode disposed at a distal end of the catheter body. The electrode includes a sidewall provided with one or more elongate gaps extending therethrough. The one or more elongate gaps providing flexibility in the sidewall for bending movement of the tip electrode relative to a longitudinal axis of the catheter body.

Type: Grant
Filed: June 5, 2013
Date of Patent: July 29, 2014
Assignee: St. Jude Medical, Atrial Fibrillation Division, Inc.
Inventors: Carlo Pappone, Alan de la Rama, Peter C Chen, Cary Hata, Jared A. Shimizu

Irrigated catheter

Patent number: 8764742

Abstract: A fluid delivery catheter configured to allow optimal fluid distribution through each electrode by varying the diameter of a catheter lumen is disclosed. Uniform or different fluid flow rates through longitudinally spaced apart elution holes may be achieved. Exemplary fluids for use with the catheter include a cooling fluid, a therapeutic fluid, and a medication.

Type: Grant
Filed: April 4, 2007
Date of Patent: July 1, 2014
Assignee: St. Jude Medical, Atrial Fibrillation Division, Inc.
Inventors: Carlo Pappone, Alan De La Rama, Peter Chen, Cary Hata

Irrigated catheter with improved fluid flow

Patent number: 8517999

Abstract: An irrigated catheter with uniform cooling and/or uniform fluid distribution in longitudinally spaced apart elution holes by varying the diameter of a fluid delivery lumen. A number of elution holes are provided in a tip region of a catheter body, and these elution holes are in fluid communication with the lumen through ducts. The fluid delivery lumen may be provided with a flow constrictor to restrict flow of fluid towards the distal region.

Type: Grant
Filed: April 4, 2007
Date of Patent: August 27, 2013
Assignee: St. Jude Medical, Atrial Fibrillation Division, Inc.
Inventors: Carlo Pappone, Alan De La Rama, Peter Chen, Cary Hata

Ablation catheter with flexible tip

Patent number: 8480669

Abstract: A flexible tip electrode for an ablation catheter is disclosed. The catheter includes a catheter body and a hollow elongate tip electrode disposed at a distal end of the catheter body. The electrode includes a sidewall provided with one or more elongate gaps extending therethrough. The one or more elongate gaps providing flexibility in the sidewall for bending movement of the tip electrode relative to a longitudinal axis of the catheter body.

Type: Grant
Filed: May 27, 2012
Date of Patent: July 9, 2013
Assignee: St. Jude Medical, Atrial Fibrillation Division, Inc.
Inventors: Carlo Pappone, Alan de la Rama, Peter Chen, Cary Hata, Jared A. Shimizu

Ablation catheter with flexible tip and methods of making the same

Patent number: 8187267

Abstract: A flexible tip electrode for an ablation catheter and methods for making the same are disclosed. The electrode has a surface configuration that improves flexibility of the electrode. Also, the surface configuration may allow electrode lengthwise freedom of movement, such that the electrode may be shortened when pressed against the target tissue. A coil may be located in the electrode to bias the electrode toward a predetermined configuration.

Type: Grant
Filed: September 11, 2007
Date of Patent: May 29, 2012
Assignee: St. Jude Medical, Atrial Fibrillation Division, Inc.
Inventors: Carlo Pappone, Alan de la Rama, Peter Chen, Cary Hata, Jared A Shimizu

Medical device guide

Pubblication number: 20100222669

Abstract: A medical device guide having an inner member having a proximal end, a distal end, and at least one lumen therein. An outer member surrounds the proximal portion of the inner member such that the distal end of the inner member projects beyond the distal end of the outer member, the portion of the inner member being sufficient flexible to flex with a guide wire extending through the lumen. The outer member is sufficiently stiff that the proximal end of the medical device guide can be engaged by a driven by a medical device advancer.

Type: Application
Filed: August 27, 2009
Publication date: September 2, 2010
Inventors: William Flickinger, Amy Raatikka, Scott Klimek, Nathan Kastelein, Gareth T. Munger, Carlo Pappone, Gabrielle Vicedomini

Method of treating cardiac arrhythmias

Patent number: 7769444

Abstract: A method of treating cardiac arrhythmias resulting from errant electrical signals conducted through the cardiac tissue from a source location. The magnitude of the errant signals is reduced by shunting electrical signals from the source location with an electrically conductive element having a sufficiently low impedance.

Type: Grant
Filed: June 29, 2006
Date of Patent: August 3, 2010
Assignee: Stereotaxis, Inc.
Inventor: Carlo Pappone

Multi-Electrode Irrigated Balloon Catheter

Patent number: 20080249463

Abstract: fluid delivery catheter configured to allow optimal fluid distribution through each electrode by varying the diameter of a catheter lumen is disclosed. Uniform or different fluid flow rates through longitudinally spaced apart elution holes may be achieved. Exemplary fluids for use with the cathere include a cooling fluid, a therapeutic fluif, and a medication.

Type: Application
Filed: April 4, 2007
Pubblication date: October 9, 2008
Inventor: Carlo Pappone, Alan De La Rama, Peter Chen, Cary Hata

When Paying Attention Pays Back: Missense Mutation c.1006G>A p. (Val336Ile) in PRKAG2 Gene Causing Left Ventricular Hypertrophy and Conduction Abnormalities in a Caucasian Patient: Case Report and Literature Review.

Micaglio E, Tondi L, Benedetti S, Schiavo MA, Camporeale A, Disabato G, Attanasio A, Guida G, Carrafiello G, Piepoli M, Spagnolo P, Pappone C, Lombardi M.

Int J Mol Sci. 2024 Aug 23;25(17):9171. doi: 10.3390/ijms25179171

PMID: 39273120

Continuous Rhythm Monitoring With Implanted Loop Recorders in Children and Adolescents With Brugada Syndrome.

Bergonti M, Ciconte G, Cruzalegui Gomez J, Crotti L, Arbelo E, Casella M, Saenen J, Rossi A, Pannone L, Martinez-Barrios E, Compagnucci P, Russo V, Berne P, Van Leuven O, Boccellino A, Marcon L, Dagradi F, Landra F, Özkartal T, Comune A, Conti S, Ribatti V, Campuzano O, Brugada P, de Asmundis C, Brugada J, Pappone C, Tondo C, Schwartz PJ, Auricchio A, Sarquella-Brugada G, Conte G.

J Am Coll Cardiol. 2024 Sep 3;84(10):921-933. doi: 10.1016/j.jacc.2024.04.070.

PMID: 39197982

NaV1.5 autoantibodies in Brugada syndrome: pathogenetic implications.

Tarantino A, Ciconte G, Melgari D, Frosio A, Ghiroldi A, Piccoli M, Villa M, Creo P, Calamaio S, Castoldi V, Coviello S, Micaglio E, Cirillo F, Locati ET, Negro G, Boccellino A, Mastrocinque F, Ćalović Ž, Ricagno S, Leocani L, Vicedomini G, Santinelli V, Rivolta I, Anastasia L, Pappone C.

Eur Heart J. 2024 Jul 30:ehae480. doi: 10.1093/eurheartj/ehae480. Online ahead of print.

PMID: 39078224

Helical superstructures between amyloid and collagen in cardiac fibrils from a patient with AL amyloidosis.

Schulte T, Chaves-Sanjuan A, Speranzini V, Sicking K, Milazzo M, Mazzini G, Rognoni P, Caminito S, Milani P, Marabelli C, Corbelli A, Diomede L, Fiordaliso F, Anastasia L, Pappone C, Merlini G, Bolognesi M, Nuvolone M, Fernández-Busnadiego R, Palladini G, Ricagno S.

Nat Commun. 2024 Jul 28;15(1):6359. doi: 10.1038/s41467-024-50686-2.

PMID: 39069558

Ablation of the epicardial substrate in patients with long-QT syndrome at risk of sudden death.

Pappone C, Boccellino A, Ciconte G, Anastasia L.

Eur Heart J Suppl. 2024 Apr 17;26(Suppl 1):i88-i92. doi: 10.1093/eurheartjsupp/suae009. eCollection 2024 Apr.

PMID: 38867856

Mode and Characteristics of Arrhythmia Initiation in Idiopathic Ventricular Fibrillation: A THESIS Substudy.

Belhassen B, Conte G, Steinberg C, Whitaker J, Khan HR, Laredo M, Doldi F, Ho R, Tadros R, Dinov B, Chorin E, Hansom S, Waintraub X, Eckardt L, Jankelson L, Peichl P, Mellor G, Sy RW, Rattanawong P, Stojkovic S, Garber L, Suna G, Kautzner J, Chan KH, Srivathsan K, Tedrow U, Havranek S, Murgatroyd F, Shauer A, Winkel BG, Page SP, Milman A, Lador A, Ayou R, Sellal JM, Chevalier P, García-Fernández FJ, Reichlin T, Shah D, Nazer B, Bermudez-Jimenez F, Nagase S, Morita H, Nam GB, Pappone C, Lambiase PD, Strohmer B, Stuehlinger M, Gandjbakhch E, Schulze-Bahr E, Krahn AD, Tovia-Brodie O; THESIS Investigators.

JACC Clin Electrophysiol. 2024 Aug;10(8):1794-1809. doi: 10.1016/j.jacep.2024.03.036. Epub 2024 Jun 5.

PMID: 38842971

The “arrhythmic” presentation of peripartum cardiomyopathy: case series and critical review of the literature.

Peretto G, Micaglio E, Ciconte G, Maia M, Luzzi M, Cariello M, Bonfanti AGR, Lazzeroni D, Anastasia L, Cavoretto P, Chieffo A, Della Bella P, Pappone C.

Front Cardiovasc Med. 2024 Mar 14;11:1362692. doi: 10.3389/fcvm.2024.1362692. eCollection 2024.

PMID: 38550516

High-risk Brugada syndrome: factors associated with arrhythmia recurrence and benefits of epicardial ablation in addition to implantable cardioverter defibrillator implantation.

Santinelli V, Ciconte G, Manguso F, Anastasia L, Micaglio E, Calovic Z, Vicedomini G, Mazza B, Vecchi M, Mecarocci V, Locati ET, Boccellino A, Negro G, Napolano A, Giannelli L, Pappone C.

Europace. 2023 Dec 28;26(1):euae019. doi: 10.1093/europace/euae019.

PMID: 38252933

Challenges in Brugada Syndrome Stratification: Investigating SCN5A Mutation Localization and Clinical Phenotypes.

Tarantino A, Ciconte G, Ghiroldi A, Mastrocinque F, Micaglio E, Boccellino A, Negro G, Piccoli M, Cirillo F, Vicedomini G, Santinelli V, Anastasia L, Pappone C.

Int J Mol Sci. 2023 Nov 23;24(23):16658. doi: 10.3390/ijms242316658.

PMID: 38068978

Electrocardiographic temporo-spatial assessment of depolarization and repolarization changes after epicardial arrhythmogenic substrate ablation in Brugada syndrome.

Locati ET, Van Dam PM, Ciconte G, Heilbron F, Boonstra M, Vicedomini G, Micaglio E, Ćalović Ž, Anastasia L, Santinelli V, Pappone C.

Eur Heart J Digit Health. 2023 Sep 6;4(6):473-487. doi: 10.1093/ehjdh/ztad050. eCollection 2023 Dec.

PMID: 38045442

Epicardial arrhythmogenic substrate in long QT syndrome.

Pappone C, Ciconte G, Vicedomini G, Anastasia L, Santinelli V.

Heart Rhythm. 2023 Dec;20(12):1782-1784. doi: 10.1016/j.hrthm.2023.07.054.

PMID: 38040481

Deep learning unmasks the ECG signature of Brugada syndrome.

Melo L, Ciconte G, Christy A, Vicedomini G, Anastasia L, Pappone C, Grant E.

PNAS Nexus. 2023 Oct 13;2(11):pgad327. doi: 10.1093/pnasnexus/pgad327. eCollection 2023 Nov.

PMID: 37937270

Unravelling Novel SCN5A Mutations Linked to Brugada Syndrome: Functional, Structural, and Genetic Insights.

Frosio A, Micaglio E, Polsinelli I, Calamaio S, Melgari D, Prevostini R, Ghiroldi A, Binda A, Carrera P, Villa M, Mastrocinque F, Presi S, Salerno R, Boccellino A, Anastasia L, Ciconte G, Ricagno S, Pappone C, Rivolta I.

Int J Mol Sci. 2023 Oct 11;24(20):15089. doi: 10.3390/ijms242015089.

PMID: 37894777

Nanobodies counteract the toxicity of an amyloidogenic light chain by stabilizing a partially open dimeric conformation.

Broggini L, Barzago MM, Speranzini V, Schulte T, Sonzini F, Giono M, Romeo M, Milani P, Caminito S, Mazzini G, Rognoni P, Merlini G, Pappone C, Anastasia L, Nuvolone M, Palladini G, Diomede L, Ricagno S.

J Mol Biol. 2023 Dec 15;435(24):168320. doi: 10.1016/j.jmb.2023.168320. Epub 2023 Oct 20.

PMID: 37865287

Interplay of Modified Sialic Acid Inhibitors and the Human Parainfluenza Virus 1 Hemagglutinin-Neuraminidase Active Site.

Rota P, La Rocca P, Bonfante F, Pagliari M, Cirillo F, Piccoli M, Ghiroldi A, Franco V, Pappone C, Allevi P, Anastasia L.

ACS Med Chem Lett. 2023 Sep 26;14(10):1383-1388. doi: 10.1021/acsmedchemlett.3c00291. eCollection 2023 Oct 12.

PMID: 37849540

The Cryo-EM STRUCTURE of Renal Amyloid Fibril Suggests Structurally Homogeneous Multiorgan Aggregation in AL Amyloidosis.

Puri S, Schulte T, Chaves-Sanjuan A, Mazzini G, Caminito S, Pappone C, Anastasia L, Milani P, Merlini G, Bolognesi M, Nuvolone M, Palladini G, Ricagno S.

J Mol Biol. 2023 Sep 15;435(18):168215. doi: 10.1016/j.jmb.2023.168215. Epub 2023 Jul 27.

PMID: 37516426

Ebstein’s anomaly in children and adults: multidisciplinary insights into imaging and therapy.

Pasqualin G, Boccellino A, Chessa M, Ciconte G, Marcolin C, Micaglio E, Pappone C, Sturla F, Giamberti A.

Heart. 2024 Jan 29;110(4):235-244. doi: 10.1136/heartjnl-2023-322420.

PMID: 37487694

Marfan Syndrome: Enhanced Diagnostic Tools and Follow-up Management Strategies.

Marelli S, Micaglio E, Taurino J, Salvi P, Rurali E, Perrucci GL, Dolci C, Udugampolage NS, Caruso R, Gentilini D, Trifiro’ G, Callus E, Frigiola A, De Vincentiis C, Pappone C, Parati G, Pini A.

Diagnostics (Basel). 2023 Jul 5;13(13):2284. doi: 10.3390/diagnostics13132284.

PMID: 37443678

Case report: Chorea and cognitive decline in a young woman: instrumental and genetic assessment of a case originally diagnosed as multiple sclerosis.

Dato C, Micaglio E, Moresco G, Rondinone O, Vitali P, Pappone C, Fontana L, Miozzo M, Bet L.

Front Genet. 2023 Jun 26;14:1129289. doi: 10.3389/fgene.2023.1129289. eCollection 2023.

PMID: 37434948

Case report: Complex arterial findings in vascular ehlers-danlos syndrome with a novel COL3A1 variant and death at young age.

Taurino J, Micaglio E, Russo Raucci A, Zanussi M, Chessa M, Udugampolage NS, Carrera P, Pappone C, Pini A.

Front Cardiovasc Med. 2023 Jun 19;10:1110392. doi: 10.3389/fcvm.2023.1110392. eCollection 2023.

PMID: 37404745

Safety and feasibility of a novel multielectrode array catheter in mapping atrial and ventricular arrhythmias with high density: results from the multicenter OPTIMUM study.

Vijgen J, Račkauskas G, Dilling-Boer D, Sarkozy A, Ciconte G, Vicedomini GG, Pappone C.

J Interv Card Electrophysiol. 2023 Oct;66(7):1563-1565. doi: 10.1007/s10840-023-01568-y. Epub 2023 May 25.

PMID: 37227536

Advances in basic and translational research in atrial fibrillation.

Hu D, Barajas-Martinez H, Zhang ZH, Duan HY, Zhao QY, Bao MW, Du YM, Burashnikov A, Monasky MM, Pappone C, Huang CX, Antzelevitch C, Jiang H.

Philos Trans R Soc Lond B Biol Sci. 2023 Jun 19;378(1879):20220174. doi: 10.1098/rstb.2022.0174. Epub 2023 May 1.

PMID: 37122214

Ablation of ventricular arrhythmias in cardiogenetic diseases.

Pappone C, Boccellino A, Ciconte G.

Eur Heart J Suppl. 2023 Apr 21;25(Suppl B):B123-B125. doi: 10.1093/eurheartjsupp/suad090. eCollection 2023 Apr.

PMID: 37091655

Analysis of the intramolecular 1,7-lactone of N-acetylneuraminic acid using HPLC-MS: relationship between detection and stability.

La Rocca P, Lavota I, Piccoli M, Cirillo F, Ghiroldi A, Ciconte G, Pappone C, Allevi P, Rota P, Anastasia L.

Glycoconj J. 2023 Jun;40(3):343-354. doi: 10.1007/s10719-023-10114-x. Epub 2023 Apr 21.

PMID: 37084126

Automated Patch-Clamp and Induced Pluripotent Stem Cell-Derived Cardiomyocytes: A Synergistic Approach in the Study of Brugada Syndrome.

Melgari D, Calamaio S, Frosio A, Prevostini R, Anastasia L, Pappone C, Rivolta I.

Int J Mol Sci. 2023 Apr 3;24(7):6687. doi: 10.3390/ijms24076687.

PMID: 37047659

Design, Synthesis, and Antiviral Evaluation of Sialic Acid Derivatives as Inhibitors of Newcastle Disease Virus Hemagglutinin-Neuraminidase: A Translational Study on Human Parainfluenza Viruses.

Rota P, La Rocca P, Bonfante F, Pagliari M, Piccoli M, Cirillo F, Ghiroldi A, Franco V, Pappone C, Allevi P, Anastasia L.

ACS Infect Dis. 2023 Mar 10;9(3):617-630. doi: 10.1021/acsinfecdis.2c00576. Epub 2023 Feb 27.

PMID: 36848501

CineECG provides a novel anatomical view on the normal atrial P-wave.

Locati ET, Pappone C, Heilbron F, van Dam PM.

Eur Heart J Digit Health. 2022 Feb 11;3(2):169-180. doi: 10.1093/ehjdh/ztac007. eCollection 2022 Jun.

PMID: 36713023

Sphingolipids and Atherosclerosis: The Dual Role of Ceramide and Sphingosine-1-Phosphate.

Piccoli M, Cirillo F, Ghiroldi A, Rota P, Coviello S, Tarantino A, La Rocca P, Lavota I, Creo P, Signorelli P, Pappone C, Anastasia L.

Antioxidants (Basel). 2023 Jan 6;12(1):143. doi: 10.3390/antiox12010143.

PMID: 36671005

Right ventricular epicardial arrhythmogenic substrate in long-QT syndrome patients at risk of sudden death.

Pappone C, Ciconte G, Anastasia L, Gaita F, Grant E, Micaglio E, Locati ET, Calovic Z, Vicedomini G, Santinelli V.

Europace. 2023 Mar 30;25(3):948-955. doi: 10.1093/europace/euac264.

PMID: 36610790

Clinical characteristics and electrophysiologic properties of SCN5A variants in fever-induced Brugada syndrome.

Chen GX, Barajas-Martínez H, Ciconte G, Wu CI, Monasky MM, Xia H, Li B, Capra JA, Guo K, Zhang ZH, Chen X, Yang B, Jiang H, Tse G, Mak CM, Aizawa Y, Gollob MH, Antzelevitch C, Wilde AAM, Pappone C, Hu D.

EBioMedicine. 2023 Jan;87:104388. doi: 10.1016/j.ebiom.2022.104388. Epub 2022 Dec 12.

PMID: 36516610

Alterations of the Sialylation Machinery in Brugada Syndrome.

Ghiroldi A, Ciconte G, Creo P, Tarantino A, Melgari D, D’Imperio S, Piccoli M, Cirillo F, Micaglio E, Monasky MM, Frosio A, Locati ET, Vicedomini G, Rivolta I, Pappone C, Anastasia L.

Int J Mol Sci. 2022 Oct 29;23(21):13154. doi: 10.3390/ijms232113154.

PMID: 36361941

A comprehensive and easy-to-use ECG algorithm to predict the coronary occlusion site in ST-segment elevation myocardial infarction.

Gaspardone C, Romagnolo D, Fasolino A, Falasconi G, Beneduce A, Fiore G, Didelon E, Fortunato F, Galdieri C, Posteraro GA, Ingallina G, Ancona F, Biondi F, Maio SD, Casiraghi A, Slavich M, Borio G, Savastano S, Leonardi S, Margonato A, Agricola E, Oppizzi M, Gaspardone A, Pappone C, Montorfano M.

Am Heart J. 2023 Jan;255:94-105. doi: 10.1016/j.ahj.2022.10.077. Epub 2022 Oct 20.

PMID: 36272451

T-Type Calcium Channels: A Mixed Blessing.

Melgari D, Frosio A, Calamaio S, Marzi GA, Pappone C, Rivolta I.

Int J Mol Sci. 2022 Aug 31;23(17):9894. doi: 10.3390/ijms23179894.

PMID: 36077291

2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death.

Zeppenfeld K, Tfelt-Hansen J, de Riva M, Winkel BG, Behr ER, Blom NA, Charron P, Corrado D, Dagres N, de Chillou C, Eckardt L, Friede T, Haugaa KH, Hocini M, Lambiase PD, Marijon E, Merino JL, Peichl P, Priori SG, Reichlin T, Schulz-Menger J, Sticherling C, Tzeis S, Verstrael A, Volterrani M; ESC Scientific Document Group.

Eur Heart J. 2022 Oct 21;43(40):3997-4126. doi: 10.1093/eurheartj/ehac262.

PMID: 36017572

Human Sarcopenic Myoblasts Can Be Rescued by Pharmacological Reactivation of HIF-1α.

Cirillo F, Mangiavini L, La Rocca P, Piccoli M, Ghiroldi A, Rota P, Tarantino A, Canciani B, Coviello S, Messina C, Ciconte G, Pappone C, Peretti GM, Anastasia L.

Int J Mol Sci. 2022 Jun 26;23(13):7114. doi: 10.3390/ijms23137114.

PMID: 35806119

Neu3 Sialidase Activates the RISK Cardioprotective Signaling Pathway during Ischemia and Reperfusion Injury (IRI).

Piccoli M, Coviello S, Canali ME, Rota P, La Rocca P, Cirillo F, Lavota I, Tarantino A, Ciconte G, Pappone C, Ghiroldi A, Anastasia L.

Int J Mol Sci. 2022 May 29;23(11):6090. doi: 10.3390/ijms23116090.

PMID: 35682772

Sudden death of a patient with epilepsy: When Brugada syndrome mimicry can be fatal.

Negro G, Ciconte G, Borrelli V, Rondine R, Maiolo V, Pappone C.

HeartRhythm Case Rep. 2021 Dec 16;8(3):205-208. doi: 10.1016/j.hrcr.2021.12.008. eCollection 2022 Mar.

PMID: 35492846

Cu(II) Binding Increases the Soluble Toxicity of Amyloidogenic Light Chains.

Russo R, Romeo M, Schulte T, Maritan M, Oberti L, Barzago MM, Barbiroli A, Pappone C, Anastasia L, Palladini G, Diomede L, Ricagno S.

Int J Mol Sci. 2022 Jan 16;23(2):950. doi: 10.3390/ijms23020950.

PMID: 35055136

The Mechanism of Ajmaline and Thus Brugada Syndrome: Not Only the Sodium Channel!

Monasky MM, Micaglio E, D’Imperio S, Pappone C.

Front Cardiovasc Med. 2021 Dec 23;8:782596. doi: 10.3389/fcvm.2021.782596. eCollection 2021.

PMID: 35004896

Letter by Romani et al Regarding Article, “Extracellular Vesicles From Epicardial Fat Facilitate Atrial Fibrillation”.

Romani F, Monasky MM, Pappone C.

Circulation. 2021 Nov 2;144(18):e280-e281. doi: 10.1161/CIRCULATIONAHA.121.055364. Epub 2021 Nov 1.

PMID: 34723643

Brugada Syndrome: Warning of a Systemic Condition?

D’Imperio S, Monasky MM, Micaglio E, Ciconte G, Anastasia L, Pappone C.

Front Cardiovasc Med. 2021 Oct 15;8:771349. doi: 10.3389/fcvm.2021.771349. eCollection 2021.

PMID: 34722688

Brugada Syndrome: New Insights From Cardiac Magnetic Resonance and Electroanatomical Imaging.

Pappone C, Santinelli V, Mecarocci V, Tondi L, Ciconte G, Manguso F, Sturla F, Vicedomini G, Micaglio E, Anastasia L, Pica S, Camporeale A, Lombardi M.

Circ Arrhythm Electrophysiol. 2021 Nov;14(11):e010004. doi: 10.1161/CIRCEP.121.010004. Epub 2021 Oct 25.

PMID: 34693720

Ventricular fibrillation ablation in cardiomyopathies and arrhythmic storm.

Pappone C, Negro G, Ciconte G.

Eur Heart J Suppl. 2021 Oct 8;23(Suppl E):E112-E117.

PMID: 34650368

Ventricular activation patterns during intrinsic conduction and right ventricular pacing in cardiac resynchronization therapy patients.

O’Donnell D, Manyam H, Pappone C, Park SJ, Leclercq C, Lunati M, Lercher P, Rordorf R, Landolina M, Badie N, McSpadden LC, Ryu K, Mangual JO, Singh JP, Varma N, Niazi IK.

Pacing Clin Electrophysiol. 2021 Oct;44(10):1663-1670

PMID: 34319603.

Further Considerations in Childhood-Onset Hypertrophic Cardiomyopathy Genetic Testing.

Monasky MM, Micaglio E, Ignaccolo S, Pappone C.

Front Cardiovasc Med. 2021 Jun 21;8:698078

PMID: 34235191

Commentary: Peptide-Based Targeting of the L-Type Calcium Channel Corrects the Loss-of-Function Phenotype of Two Novel Mutations of the CACNA1 Gene Associated With Brugada Syndrome.

Monasky MM, Rutigliani C, Micaglio E, Pappone C.

Front Physiol. 2021 Jun 9;12:682567

PMID: 34177625

Early Morning QT Prolongation During Hypoglycemia: Only a Matter of Glucose?

D’Imperio S, Monasky MM, Micaglio E, Negro G, Pappone C.

Front Cardiovasc Med. 2021 May 11;8:688875

PMID: 34046442

Intramolecular Lactones of Sialic Acids.

Rota P, La Rocca P, Allevi P, Pappone C, Anastasia L.

Int J Mol Sci. 2020 Oct 30;21(21):8098

PMID: 33143039

Assessing QT interval in COVID-19 patients:safety of hydroxychloroquine-azithromycin combination regimen.

Bernardini A, Ciconte G, Negro G, Rondine R, Mecarocci V, Viva T, Santini F, de Innocentiis C, Giannelli L, Witkowska E, Locati ET, Castelvecchio S, Marrocco-Trischitta MM, Vicedomini G, Menicanti L, Pappone C.

Int J Cardiol. 2021 Feb 1;324:242-248

PMID: 32956782

AFA LT registry Italian investigators group. Atrial fibrillation ablation long-term ESC-EHRA EORP AFA LT registry: in-hospital and 1-year follow-up findings in Italy.

Anselmino M, Ballatore A, Saglietto A, Stabile G, De Ponti R, Grimaldi M, Agricola PMG, Della Bella P, Tritto M, Pappone C, Calò L, Bongiorni MG, Blomström-Lundqvist C, Gaita F, De Ferrari GM;

J Cardiovasc Med (Hagerstown). 2020 Oct;21(10):740-748

PMID: 32898381.

Role of sialidase Neu3 and ganglioside GM3 in cardiac fibroblasts activation.

Ghiroldi A, Piccoli M, Creo P, Cirillo F, Rota P, D’Imperio S, Ciconte G, Monasky MM, Micaglio E, Garatti A, Aureli M, Carsana EV, Menicanti L, Pappone C, Anastasia L.

Biochem J. 2020 Sep 18;477(17):3401-3415

PMID: 32869836.

Novel SCN5A p.V1429M Variant Segregation in a Family with Brugada Syndrome.

Monasky MM, Micaglio E, Ciconte G, Borrelli V, Giannelli L, Vicedomini G, Ghiroldi A, Anastasia L, Locati ET, Benedetti S, Di Resta C, Casari G, Pappone C.

Int J Mol Sci. 2020 Aug 17;21(16):5902

PMID: 32824506

Novel CineECG Derived From Standard 12-Lead ECG Enables Right Ventricle Outflow Tract Localization of Electrical Substrate in Patients With Brugada Syndrome.

van Dam PM, Locati ET, Ciconte G, Borrelli V, Heilbron F, Santinelli V, Vicedomini G, Monasky MM, Micaglio E, Giannelli L, Mecarocci V, Ćalović Ž, Anastasia L, Pappone C.

Circ Arrhythm Electrophysiol. 2020 Sep;13(9):e008524

PMID: 32755392.

Electrical synchronization achieved by multipoint pacing combined with dynamic atrioventricular delay.

O’Donnell D, Wisnoskey B, Badie N, Odgers L, Smart T, Ord M, Lin T, Mangual JO, Cranke G, McSpadden LC, Ryu K, Bianchi V, D’Onofrio A, Pappone C, Calò L, Chow A, Betts TR, Thibault B, Varma N.

J Interv Card Electrophysiol. 2021 Sep;61(3):453-460

PMID: 32740689.

Right ventricular electromechanical abnormalities in Brugada syndrome: is this a cardiomyopathy?

Pappone C, Monasky MM, Micaglio E, Ciconte G.

Eur Heart J Suppl. 2020 Jun;22(Suppl E):E101-E104

PMID: 32523450

Impact of Dietary Factors on Brugada Syndrome and Long QT Syndrome.

D’Imperio S, Monasky MM, Micaglio E, Negro G, Pappone C.

Nutrients. 2021 Jul 21;13(8):2482.

PMID: 34444641

(Brugada Syndrome: Warning of a systemic condition?/abstract

D’Imperio S, Monasky MM, Micaglio E, Ciconte G, Anastasia L, Pappone C.

Front Cardiovasc Med. 2021

Role of Pharmacogenetics in Adverse Drug Reactions: An Update towards Personalized Medicine.

Micaglio E, Locati ET, Monasky MM, Romani F, Heilbron F, Pappone C.

Front Pharmacol. 2021 Apr 30;12:651720. doi: 10.3389/fphar.2021.651720. eCollection 2021.

PMID: 33995067

Evaluating the Use of Genetics in Brugada Syndrome Risk Stratification.

Monasky MM, Micaglio E, Locati ET, Pappone C.

Front Cardiovasc Med. 2021 Apr 21;8:652027. doi: 10.3389/fcvm.2021.652027. eCollection 2021.

PMID: 33969014

Novel SCN5A p.Val1667Asp Missense Variant Segregation and Characterization in a Family with Severe Brugada Syndrome and Multiple Sudden Deaths.

Monasky MM, Micaglio E, Ciconte G, Rivolta I, Borrelli V, Ghiroldi A, D’Imperio S, Binda A, Melgari D, Benedetti S, Mitrovic P, Anastasia L, Mecarocci V, Ćalović Ž, Casari G, Pappone C.

Int J Mol Sci. 2021 Apr 29;22(9):4700. doi: 10.3390/ijms22094700.

PMID: 33946750

Second-generation laser balloon ablation for the treatment of atrial fibrillation assessed by continuous rhythm monitoring: the LIGHT-AF study.

Rovaris G, Ciconte G, Schiavone M, Mitacchione G, Gasperetti A, Piazzi E, Negro G, Montemerlo E, Rondine R, Pozzi M, Casiraghi M, De Ceglia S, Giacopelli D, Viecca M, Vicedomini G, Forleo GB, Pappone C.

Europace. 2021 Apr 9:euab085. doi: 10.1093/europace/euab085. Online ahead of print.

PMID: 33837418

The omics of channelopathies and cardiomyopathies: what we know and how they are useful.

Pappone C, Micaglio E, Locati ET, Monasky

MM.Eur Heart J Suppl. 2020 Nov 18;22(Suppl L):L105-L109. doi: 10.1093/eurheartj/suaa146. eCollection 2020 Nov.

PMID: 33654474

Case Report: Efficacy of Rituximab in a Patient With Familial Mediterranean Fever and Multiple Sclerosis.

Pozzato M, Micaglio E, Starvaggi Cucuzza C, Cagol A, Galimberti D, Calandrella D, Cinnante C, Pappone C, Zanussi M, Meola G, Scarpini E, Bresolin N, Martinelli Boneschi

F.Front Neurol. 2021 Jan 6;11:591395. doi: 10.3389/fneur.2020.591395. eCollection 2020.

PMID: 33584496

Common modulators of Brugada syndrome phenotype do not affect SCN5A prognostic value.

Pappone C, Ciconte G, Micaglio E, Monasky MM.Eur Heart J. 2021 Mar 31;42(13):1273-1274. doi: 10.1093/eurheartj/ehab071.

PMID: 33595071

Clinical Considerations for a Family with Dilated Cardiomyopathy, Sudden Cardiac Death, and a Novel TTN Frameshift Mutation.

Micaglio E, Monasky MM, Bernardini A, Mecarocci V, Borrelli V, Ciconte G, Locati ET, Piccoli M, Ghiroldi A, Anastasia L, Pappone C.

Int J Mol Sci. 2021 Jan 12;22(2):670. doi: 10.3390/ijms22020670.

PMID: 33445410

The antithetic role of ceramide and sphingosine-1-phosphate in cardiac dysfunction.

Cirillo F, Piccoli M, Ghiroldi A, Monasky MM, Rota P, La Rocca P, Tarantino A, D’Imperio S, Signorelli P, Pappone C, Anastasia L.

J Cell Physiol. 2021 Jul;236(7):4857-4873. doi: 10.1002/jcp.30235. Epub 2021 Jan 11.

PMID: 33432663 Review.

HIF-1α Directly Controls WNT7A Expression During Myogenesis.

Cirillo F, Resmini G, Angelino E, Ferrara M, Tarantino A, Piccoli M, Rota P, Ghiroldi A, Monasky MM, Ciconte G, Pappone C, Graziani A, Anastasia L.

Front Cell Dev Biol. 2020 Nov 11;8:593508. doi: 10.3389/fcell.2020.593508. eCollection 2020.

PMID: 33262987

Brugada syndrome genetics is associated with phenotype severity.

Ciconte G, Monasky MM, Santinelli V, Micaglio E, Vicedomini G, Anastasia L, Negro G, Borrelli V, Giannelli L, Santini F, de Innocentiis C, Rondine R, Locati ET, Bernardini A, Mazza BC, Mecarocci V, Ćalović Ž, Ghiroldi A, D’Imperio S, Benedetti S, Di Resta C, Rivolta I, Casari G, Petretto E,Pappone C.

European heart journal 2020 Nov 21;ehaa942. doi: 10.1093/eurheartj/ehaa942.

PMID: 33221895

Intramolecular Lactones of Sialic Acids.

Rota P, La Rocca P, Allevi P, Pappone C, Anastasia L.

Int J Mol Sci. 2020 Oct 30;21(21):8098. doi: 10.3390/ijms21218098.

PMID: 33143039

Assessing QT interval in COVID-19 patients: Safety of Hydroxychloroquine-azithromycin combination regimen.

Bernardini A, Ciconte G, Negro G, Rondine R, Mecarocci V, Viva T, Santini F, de Innocentiis C, Giannelli L, Witkowska E, Locati ET, Castelvecchio S, Marrocco-Trischitta M, Vicedomini G, Menicanti L, Pappone C.

Int J Cardiol. 2020 Sep 18:S0167-5273(20)33819-5. doi: 10.1016/j.ijcard.2020.09.038.

PMID: 32956782

Atrial fibrillation ablation long-term ESC-EHRA EORP AFA LT registry: in-hospital and 1-year follow-up findings in Italy.

Anselmino M, Ballatore A, Saglietto A, Stabile G, De Ponti R, Grimaldi M, Agricola PMG, Della Bella P, Tritto M, Pappone C, Calò L, Bongiorni MG, Blomström-Lundqvist C, Gaita F, De Ferrari GM;

AFA LT registry Italian investigators group.J Cardiovasc Med (Hagerstown). 2020 Oct;21(10):740-748. doi: 10.2459/JCM.0000000000000999.

PMID: 32898381

Role of sialidase Neu3 and ganglioside GM3 in cardiac fibroblasts activation.

Ghiroldi A, Piccoli M, Creo P, Cirillo F, Rota P, D’Imperio S, Ciconte G, Monasky MM, Micaglio E, Garatti A, Aureli M, Carsana EV, Menicanti L, Pappone C, Anastasia L.Biochem J.

2020 Sep 18;477(17):3401-3415. doi: 10.1042/BCJ20200360.

PMID: 32869836

Novel SCN5A p.V1429M Variant Segregation in a Family with Brugada Syndrome.

Monasky MM, Micaglio E, Ciconte G, Borrelli V, Giannelli L, Vicedomini G, Ghiroldi A, Anastasia L, Locati ET, Benedetti S, Di Resta C, Casari G, Pappone C.

Int J Mol Sci. 2020 Aug 17;21(16):5902. doi: 10.3390/ijms21165902.

PMID: 32824506

Novel CineECG Derived From Standard 12-Lead ECG Enables Right Ventricle Outflow Tract Localization of Electrical Substrate in Patients With Brugada Syndrome.

van Dam PM, Locati ET, Ciconte G, Borrelli V, Heilbron F, Santinelli V, Vicedomini G, Monasky MM, Micaglio E, Giannelli L, Mecarocci V, Ćalović Ž, Anastasia L, Pappone C.

Circ Arrhythm Electrophysiol. 2020 Sep;13(9):e008524. doi: 10.1161/CIRCEP.120.008524. Epub 2020 Jul 28.

PMID: 32755392

Electrical synchronization achieved by multipoint pacing combined with dynamic atrioventricular delay.

O’Donnell D, Wisnoskey B, Badie N, Odgers L, Smart T, Ord M, Lin T, Mangual JO, Cranke G, McSpadden LC, Ryu K, Bianchi V, D’Onofrio A, Pappone C, Calò L, Chow A, Betts TR, Thibault B, Varma N.J

Interv Card Electrophysiol. 2020 Aug 1. doi: 10.1007/s10840-020-00842-7.

PMID: 32740689

Right ventricular electromechanical abnormalities in Brugada syndrome: is this a cardiomyopathy?

Pappone C, Monasky MM, Micaglio E, Ciconte G.

Eur Heart J Suppl. 2020 Jun;22(Suppl E):E101-E104. doi: 10.1093/eurheartj/suaa071. Epub 2020 Mar 25.

PMID: 32523450

Brugada Syndrome: Oligogenic or Mendelian Disease?

Monasky MM, Micaglio E, Ciconte G, Pappone C.

Int J Mol Sci. 2020 Mar 1;21(5). pii: E1687. doi: 10.3390/ijms21051687. Review.

PMID: 32121523

Novel JAG1 Deletion Variant in Patient with Atypical Alagille Syndrome.

Micaglio E, Andronache AA, Carrera P, Monasky MM, Locati ET, Pirola B, Presi S, Carminati M, Ferrari M, Giamberti A, Pappone C.

Int J Mol Sci. 2019 Dec 11;20(24). pii: E6247. doi: 10.3390/ijms20246247.

PMID: 31835735

New electromechanical substrate abnormalities in high-risk patients with Brugada syndrome.

Pappone C, Mecarocci V, Manguso F, Ciconte G, Vicedomini G, Sturla F, Votta E, Mazza B, Pozzi P, Borrelli V, Anastasia L, Micaglio E, Locati E, Monasky M, Lombardi M, Calovic Z, Santinelli V.

Heart Rhythm. 2019 Nov 19. pii: S1547-5271(19)31031-8. doi: 10.1016/j.hrthm.2019.11.019. [Epub ahead of print]

PMID: 31756528

Genotype-Phenotype Correlation in a Family with Brugada Syndrome Harboring the Novel p.Gln371* Nonsense Variant in the SCN5A Gene.

Monasky MM, Micaglio E, Giachino D, Ciconte G, Giannelli L, Locati ET, Ramondini E, Cotugno R, Vicedomini G, Borrelli V, Ghiroldi A, Anastasia L, Pappone C.

Int J Mol Sci. 2019 Nov 6;20(22). pii: E5522. doi: 10.3390/ijms20225522.

PMID: 31698696

Dynamic atrioventricular delay programming improves ventricular electrical synchronization as evaluated by 3D vectorcardiography.

Engels EB, Thibault B, Mangual J, Badie N, McSpadden LC, Calò L, Ritter P, Pappone C, Bode K, Varma N, Prinzen FW.

J Electrocardiol. 2019 Oct 20;58:1-6. doi: 10.1016/j.jelectrocard.2019.09.026. [Epub ahead of print]

PMID: 31677533

Non-invasive assessment of the arrhythmogenic substrate in Brugada syndrome using signal-averaged electrocardiogram: clinical implications from a prospective clinical trial.

Ciconte G, Santinelli V, Vicedomini G, Borrelli V, Monasky MM, Micaglio E, Giannelli L, Negro G, Giordano F, Mecarocci V, Mazza BC, Locati E, Anastasia L, Calovic Z, Pappone C.

Europace. 2019 Oct 24. pii: euz295. doi: 10.1093/europace/euz295. [Epub ahead of print]

PMID: 31647530

Novel SCN5A p.W697X Nonsense Mutation Segregation in a Family with Brugada Syndrome.

Micaglio E, Monasky MM, Resta N, Bagnulo R, Ciconte G, Gianelli L, Locati ET, Vicedomini G, Borrelli V, Ghiroldi A, Anastasia L, Benedetti S, Di Resta C, Ferrari M, Pappone C.

Int J Mol Sci. 2019 Oct 4;20(19). pii: E4920. doi: 10.3390/ijms20194920.

PMID: 31590245

Out-of-hospital cardiac arrest due to idiopathic ventricular fibrillation in patients with normal electrocardiograms: results from a multicentre long-term registry.

Conte G, Belhassen B, Lambiase P, Ciconte G, de Asmundis C, Arbelo E, Schaer B, Frontera A, Burri H, Calo’ L, Letsas KP, Leyva F, Porter B, Saenen J, Zacà V, Berne P, Ammann P, Zardini M, Luani B, Rordorf R, Sarquella Brugada G, Medeiros-Domingo A, Geller JC, de Potter T, Stokke MK, Márquez MF, Michowitz Y, Honarbakhsh S, Conti M, Sticherling C, Martino A, Zegard A, Özkartal T, Caputo ML, Regoli F, Braun-Dullaeus RC, Notarangelo F, Moccetti T, Casu G, Rinaldi CA, Levinstein M, Haugaa KH, Derval N, Klersy C, Curti M, Pappone C, Heidbuchel H, Brugada J, Haïssaguerre M, Brugada P, Auricchio A.

Europace. 2019 Nov 1;21(11):1670-1677. doi: 10.1093/europace/euz221.

PMID: 31504477

Sphingolipid Synthesis Inhibition by Myriocin Administration Enhances Lipid Consumption and Ameliorates Lipid Response to Myocardial Ischemia Reperfusion Injury.

Bonezzi F, Piccoli M, Dei Cas M, Paroni R, Mingione A, Monasky MM, Caretti A, Riganti C, Ghidoni R, Pappone C, Anastasia L, Signorelli P.

Front Physiol. 2019 Aug 9;10:986. doi: 10.3389/fphys.2019.00986. eCollection 2019.

PMID: 31447688

Comparable clinical characteristics in Brugada syndrome patients harboring SCN5A or novel SCN10A variants.

Monasky MM, Micaglio E, Vicedomini G, Locati ET, Ciconte G, Giannelli L, Giordano F, Crisà S, Vecchi M, Borrelli V, Ghiroldi A, D’Imperio S, Resta CD, Benedetti S, Ferrari M, Santinelli V, Anastasia L, Pappone C.

Europace. 2019 Jul 10. pii: euz186. doi: 10.1093/europace/euz186. [Epub ahead of print]

Novel SCN5A Frameshift Mutation in Brugada Syndrome Associated With Complex Arrhythmic Phenotype.

Micaglio E, Monasky MM, Ciconte G, Vicedomini G, Conti M, Mecarocci V, Giannelli L, Giordano F, Pollina A, Saviano M, Pozzi PR, Di Resta C, Benedetti S, Ferrari M, Santinelli V, Pappone C.

Front Genet. 2019 Jun 6;10:547. doi: 10.3389/fgene.2019.00547. eCollection 2019.

Genotype/Phenotype Relationship in a Consanguineal Family With Brugada Syndrome Harboring the R1632C Missense Variant in the SCN5A Gene.

Monasky MM, Micaglio E, Ciconte G, Benedetti S, Di Resta C, Vicedomini G, Borrelli V, Ghiroldi A, Piccoli M, Anastasia L, Santinelli V, Ferrari M, Pappone C.

Front Physiol. 2019 May 28;10:666. doi: 10.3389/fphys.2019.00666. eCollection 2019.

Unusual response to ajmaline test in Brugada syndrome patient leads to extracorporeal membrane oxygenator support.

Ciconte G, Monasky MM, Vicedomini G, Borrelli V, Giannelli L, Pappone C.

Europace. 2019 Jun 3. pii: euz139. doi: 10.1093/europace/euz139. [Epub ahead of print] No abstract available.

Arrhythmias due to Inherited and Acquired Abnormalities of Ventricular Repolarization.

Locati ET, Bagliani G, Cecchi F, Johny H, Lunati M, Pappone C.

Card Electrophysiol Clin. 2019 Jun;11(2):345-362. doi: 10.1016/j.ccep.2019.02.009. Epub 2019 Apr 10. Review.

Non-paroxysmal atrial fibrillation mapping: characterization of the electrophysiological substrate using a novel integrated mapping technique.

Ciconte G, Vicedomini G, Li W, Mangual JO, McSpadden L, Ryu K, Saviano M, Vitale R, Conti M, Ćalović Ž, Santinelli V, Pappone C.

Europace. 2019 May 5. pii: euz123. doi: 10.1093/europace/euz123. [Epub ahead of print]

Epicardial ablation in genetic cardiomyopathies: a new frontier.

Pappone C, Monasky MM, Ciconte G.

Eur Heart J Suppl. 2019 Mar;21(Suppl B):B61-B66. doi: 10.1093/eurheartj/suz028. Epub 2019 Mar 29. Erratum in: Eur Heart J Suppl. 2019 Mar;21(Suppl B):B108.

Brugada Syndrome: Progress in Diagnosis and Management.

Pappone C, Santinelli V.

Arrhythm Electrophysiol Rev. 2019 Mar;8(1):13-18. doi: 10.15420/aer.2018.73.2. Review.

Left Atrial Dynamics During Exercise in Mitral Regurgitation of Primary and Secondary Origin: Pathophysiological Insights by Exercise Echocardiography Combined With Gas Exchange Analysis.

Sugimoto T, Bandera F, Generati G, Alfonzetti E, Barletta M, Losito M, Labate V, Rovida M, Caracciolo M, Pappone C, Ciconte G, Guazzi M.

JACC Cardiovasc Imaging. 2019 Mar 13. pii: S1936-878X(19)30162-7. doi: 10.1016/j.jcmg.2018.12.031. [Epub ahead of print]

SCN5A Nonsense Mutation and NF1 Frameshift Mutation in a Family With Brugada Syndrome and Neurofibromatosis.

Micaglio E, Monasky MM, Ciconte G, Vicedomini G, Conti M, Mecarocci V, Giannelli L, Giordano F, Pollina A, Saviano M, Crisà S, Borrelli V, Ghiroldi A, D’Imperio S, Di Resta C, Benedetti S, Ferrari M, Santinelli V, Anastasia L, Pappone C.

Front Genet. 2019 Feb 15;10:50. doi: 10.3389/fgene.2019.00050. eCollection 2019.

Dynamic programming of atrioventricular delay improves electrical synchrony in a multicenter cardiac resynchronization therapy study.

Thibault B, Ritter P, Bode K, Calò L, Mondésert B, Mangual JO, Badie N, McSpadden LC, Pappone C, Varma N.

Heart Rhythm. 2019 Jul;16(7):1047-1056. doi: 10.1016/j.hrthm.2019.01.020. Epub 2019 Jan 23.

Reversine: A Synthetic Purine with a Dual Activity as a Cell Dedifferentiating Agent and a Selective Anticancer Drug.

Piccoli M, Ghiroldi A, Monasky MM, Cirillo F, Ciconte G, Pappone C, Anastasia L.

Curr Med Chem. 2019 Jan 3. doi: 10.2174/0929867326666190103120725. [Epub ahead of print]

Surgical ablation of ventricular tachycardia in patients with repaired tetralogy of Fallot†.

Caldaroni F, Lo Rito M, Chessa M, Varrica A, Micheletti A, Pappone C, Giamberti A.

Eur J Cardiothorac Surg. 2019 May 1;55(5):845-850. doi: 10.1093/ejcts/ezy407.

Multipoint left ventricular pacing improves response to cardiac resynchronization therapy with and without pressure-volume loop optimization: comparison of the long-term efficacy of two different programming strategies.

Ciconte G, Ćalović Ž, McSpadden LC, Ryu K, Mangual J, Caporaso I, Baldi M, Saviano M, Cuko A, Vitale R, Conti M, Giannelli L, Vicedomini G, Santinelli V, Pappone C.

J Interv Card Electrophysiol. 2019 Mar;54(2):141-149. doi: 10.1007/s10840-018-0480-6. Epub 2018 Nov 27.

Cell-Based Therapies for Cardiac Regeneration: A Comprehensive Review of Past and Ongoing Strategies.

Ghiroldi A, Piccoli M, Cirillo F, Monasky MM, Ciconte G, Pappone C, Anastasia L.

Int J Mol Sci. 2018 Oct 16;19(10). pii: E3194. doi: 10.3390/ijms19103194. Review.

Impact of body mass index on the outcome of catheter ablation of atrial fibrillation.

Glover BM, Hong KL, Dagres N, Arbelo E, Laroche C, Riahi S, Bertini M, Mikhaylov EN, Galvin J, Kiliszek M, Pokushalov E, Kautzner J, Calvo N, Blomström-Lundqvist C, Brugada J; ESC-EHRA Atrial Fibrillation Ablation Long-Term Registry investigators.

Heart. 2019 Feb;105(3):244-250. doi: 10.1136/heartjnl-2018-313490. Epub 2018 Oct 2.

GM1 Ganglioside Promotes Osteogenic Differentiation of Human Tendon Stem Cells.

Bergante S, Creo P, Piccoli M, Ghiroldi A, Menon A, Cirillo F, Rota P, Monasky MM, Ciconte G, Pappone C, Randelli P, Anastasia L.

Stem Cells Int. 2018 Aug 23;2018:4706943. doi: 10.1155/2018/4706943. eCollection 2018.

Calcium in Brugada Syndrome: Questions for Future Research.

Monasky MM, Pappone C, Piccoli M, Ghiroldi A, Micaglio E, Anastasia L.

Front Physiol. 2018 Aug 10;9:1088. doi: 10.3389/fphys.2018.01088. eCollection 2018. Review.

Feasibility of Remote Monitoring Using a Novel Long-Dipole Insertable Cardiac Monitor.

Ciconte G, Vicedomini G, Giacopelli D, Calovic Z, Conti M, Spinelli B, Saviano M, Santinelli V, Pappone C.

JACC Clin Electrophysiol. 2018 Apr;4(4):559-561. doi: 10.1016/j.jacep.2017.12.018. No abstract available.

General Anesthesia Attenuates Brugada Syndrome Phenotype Expression: Clinical Implications From a Prospective Clinical Trial.

Ciconte G, Santinelli V, Brugada J, Vicedomini G, Conti M, Monasky MM, Borrelli V, Castracane W, Aloisio T, Giannelli L, Di Dedda U, Pozzi P, Ranucci M, Pappone C.

JACC Clin Electrophysiol. 2018 Apr;4(4):518-530. doi: 10.1016/j.jacep.2017.11.013. Epub 2018 Feb 13.

Flecainide-Induced Brugada Syndrome in a Patient With Skeletal Muscle Sodium Channelopathy: A Case Report With Critical Therapeutical Implications and Review of the Literature.

Cavalli M, Fossati B, Vitale R, Brigonzi E, Ricigliano VAG, Saraceno L, Cardani R, Pappone C, Meola G.

Front Neurol. 2018 May 30;9:385. doi: 10.3389/fneur.2018.00385. eCollection 2018.

Atrial Fibrillation in Autoimmune Rheumatic Diseases: from Pathogenesis to Treatment.

Ciconte G, Conti M, Evangelista M, Pappone C.

Rev Recent Clin Trials. 2018;13(3):170-175. doi: 10.2174/1574887113666180418110721. Review.

Assessing the Malignant Ventricular Arrhythmic Substrate in Patients With Brugada Syndrome.

Pappone C, Ciconte G, Manguso F, Vicedomini G, Mecarocci V, Conti M, Giannelli L, Pozzi P, Borrelli V, Menicanti L, Calovic Z, Della Ratta G, Brugada J, Santinelli V.

J Am Coll Cardiol. 2018 Apr 17;71(15):1631-1646. doi: 10.1016/j.jacc.2018.02.022.

Ablation for persistent atrial fibrillation in patients with heart failure: is it underutilized?

Pappone C, Santinelli V.

J Cardiovasc Med (Hagerstown). 2018 Feb;19 Suppl 1:e99-e102. doi: 10.2459/JCM.0000000000000645. Review. No abstract available.

Clinical Outcome of Electrophysiologically Guided Ablation for Nonparoxysmal Atrial Fibrillation Using a Novel Real-Time 3-Dimensional Mapping Technique: Results From a Prospective Randomized Trial.

Pappone C, Ciconte G, Vicedomini G, Mangual JO, Li W, Conti M, Giannelli L, Lipartiti F, McSpadden L, Ryu K, Guazzi M, Menicanti L, Santinelli V.

Circ Arrhythm Electrophysiol. 2018 Mar;11(3):e005904. doi: 10.1161/CIRCEP.117.005904.

Programming Cardiac Resynchronization Therapy for Electrical Synchrony: Reaching Beyond Left Bundle Branch Block and Left Ventricular Activation Delay.

Varma N, O’Donnell D, Bassiouny M, Ritter P, Pappone C, Mangual J, Cantillon D, Badie N, Thibault B, Wisnoskey B.

J Am Heart Assoc. 2018 Feb 6;7(3). pii: e007489. doi: 10.1161/JAHA.117.007489.

Commentary: Next Generation Sequencing and Linkage Analysis for the Molecular Diagnosis of a Novel Overlapping Syndrome Characterized by Hypertrophic Cardiomyopathy and Typical Electrical Instability of Brugada Syndrome.

Monasky MM, Ciconte G, Anastasia L, Pappone C.

Front Physiol. 2017 Dec 12;8:1056. doi: 10.3389/fphys.2017.01056. eCollection 2017. No abstract available.

The Role of Implantable Cardiac Monitors in Atrial Fibrillation Management.

Ciconte G, Giacopelli D, Pappone C.

J Atr Fibrillation. 2017 Aug 31;10(2):1590. doi: 10.4022/jafib.1590. eCollection 2017 Aug-Sep. Review.

Multipoint pacing improves peripheral hemodynamic response: Noninvasive assessment using radial artery tonometry.

Ciconte G, Ćalović Ž, Vicedomini G, Cuko A, McSpadden LC, Jiang C, Ryu K, Caporaso I, Stutz R, Winter D, Saviano M, Vitale R, Conti M, Santinelli V, Pappone C.

Pacing Clin Electrophysiol. 2018 Feb;41(2):106-113. doi: 10.1111/pace.13254. Epub 2018 Jan 8.

How to map persistent atrial fribillation and increase efficacy of ablation therapy.

Pappone C.

Rev Port Cardiol. 2017 Nov;36 Suppl 1:29-30. doi: 10.1016/j.repc.2017.09.009. Epub 2017 Nov 9. English, Portuguese. No abstract available.

Regenerating the human heart: direct reprogramming strategies and their current limitations.

Ghiroldi A, Piccoli M, Ciconte G, Pappone C, Anastasia L.

Basic Res Cardiol. 2017 Oct 27;112(6):68. doi: 10.1007/s00395-017-0655-9. Review.

Thrombosis on a left atrial appendage occluder device: the double-edged sword of stroke prevention strategies in atrial fibrillation.

Ciconte G, Conti M, Baldi M, Saviano M, Vicedomini G, Pappone C.

J Cardiovasc Med (Hagerstown). 2017 Nov;18(11):920-921. doi: 10.2459/JCM.0000000000000570.

Intermittent alternance of Brugada ECG patterns: Insights from a unique electrophysiological phenomenon.

Ciconte G, Conti M, Vicedomini G, Santinelli V, Brugada J, Pappone C.

J Cardiovasc Electrophysiol. 2017 Dec;28(12):1482-1484. doi: 10.1111/jce.13317. Epub 2017 Sep 13. No abstract available.

Ventricular Arrhythmias Ablation in Brugada Syndrome. Current and Future Directions.

Pappone C, Brugada J.

Rev Esp Cardiol (Engl Ed). 2017 Dec;70(12):1046-1049. doi: 10.1016/j.rec.2017.06.018. Epub 2017 Jul 19. English, Spanish. No abstract available.

Electrical Substrate Elimination in 135 Consecutive Patients With Brugada Syndrome.

Pappone C, Brugada J, Vicedomini G, Ciconte G, Manguso F, Saviano M, Vitale R, Cuko A, Giannelli L, Calovic Z, Conti M, Pozzi P, Natalizia A, Crisà S, Borrelli V, Brugada R, Sarquella-Brugada G, Guazzi M, Frigiola A, Menicanti L, Santinelli V.

Circ Arrhythm Electrophysiol. 2017 May;10(5):e005053. doi: 10.1161/CIRCEP.117.005053.

Additional electrodes on the Quartet™ LV lead provide more programmable pacing options than bipolar and tripolar equivalents.

O’Donnell D, Sperzel J, Thibault B, Rinaldi CA, Pappone C, Gutleben KJ, Leclercq C, Razavi H, Ryu K, Mcspadden LC, Fischer A, Tomassoni G.

Europace. 2017 Apr 1;19(4):588-595. doi: 10.1093/europace/euw039.

Executive Summary: European Heart Rhythm Association Consensus Document on the Management of Supraventricular Arrhythmias: Endorsed by Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS), and Sociedad Latinoamericana de Estimulación Cardiaca y Electrofisiologia (SOLAECE).

Katritsis DG, Boriani G, Cosio FG, Jais P, Hindricks G, Josephson ME, Keegan R, Knight BP, Kuck KH, Lane DA, Lip GY, Malmborg H, Oral H, Pappone C, Themistoclakis S, Wood KA, Young-Hoon K, Lundqvist CB.

Arrhythm Electrophysiol Rev. 2016;5(3):210-224. doi: 10.15420/aer.2016:5.3.GL1.

European Heart Rhythm Association (EHRA) consensus document on the management of supraventricular arrhythmias, endorsed by Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS), and Sociedad Latinoamericana de Estimulación Cardiaca y Electrofisiologia (SOLAECE).

Katritsis DG, Boriani G, Cosio FG, Hindricks G, Jaïs P, Josephson ME, Keegan R, Kim YH, Knight BP, Kuck KH, Lane DA, Lip GY, Malmborg H, Oral H, Pappone C, Themistoclakis S, Wood KA, Blomström-Lundqvist C, Gorenek B, Dagres N, Dan GA, Vos MA, Kudaiberdieva G, Crijns H, Roberts-Thomson K, Lin YJ, Vanegas D, Caorsi WR, Cronin E, Rickard J.

Europace. 2017 Mar 1;19(3):465-511. doi: 10.1093/europace/euw301. Review. No abstract available. Erratum in: Europace. 2017 Apr 1;19(4):659.

European Heart Rhythm Association (EHRA) consensus document on the management of supraventricular arrhythmias, endorsed by Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS), and Sociedad Latinoamericana de Estimulación Cardiaca y Electrofisiologia (SOLAECE).

Katritsis DG, Boriani G, Cosio FG, Hindricks G, Jais P, Josephson ME, Keegan R, Kim YH, Knight BP, Kuck KH, Lane DA, Lip GYH, Malmborg H, Oral H, Pappone C, Themistoclakis S, Wood KA, Blomström-Lundqvist C.

Eur Heart J. 2018 Apr 21;39(16):1442-1445. doi: 10.1093/eurheartj/ehw455. No abstract available.

Implantable cardioverter defibrillator and catheter ablation in Brugada syndrome.

Pappone C, Santinelli V.

J Cardiovasc Med (Hagerstown). 2017 Jan;18 Suppl 1:e35-e39. doi: 10.2459/JCM.0000000000000449. No abstract available.

Surgery for supraventricular tachycardia and congenital heart defects: long-term efficacy of the combined approach in adult patients.

Giamberti A, Pluchinotta FR, Chessa M, Varrica A, Vitale R, Frigiola A, Pappone C, Ranucci M.

Europace. 2017 Sep 1;19(9):1542-1548. doi: 10.1093/europace/euw278.

Atrial fibrillation detection using a novel three-vector cardiac implantable monitor: the atrial fibrillation detect study.

Ciconte G, Saviano M, Giannelli L, Calovic Z, Baldi M, Ciaccio C, Cuko A, Vitale R, Giacopelli D, Conti M, Lipartiti F, Giordano F, Maresca F, Moscatiello M, Vicedomini G, Santinelli V, Pappone C.

Europace. 2017 Jul 1;19(7):1101-1108. doi: 10.1093/europace/euw181.

Radiofrequency Ablation Versus Antiarrhythmic Drug Therapy for Atrial Fibrillation: Meta-Analysis of Quality of Life, Morbidity, and Mortality.

Siontis KC, Ioannidis JPA, Katritsis GD, Noseworthy PA, Packer DL, Hummel JD, Jais P, Krittayaphong R, Mont L, Morillo CA, Nielsen JC, Oral H, Pappone C, Santinelli V, Weerasooriya R, Wilber DJ, Gersh BJ, Josephson ME, Katritsis DG.

JACC Clin Electrophysiol. 2016 Apr;2(2):170-180. doi: 10.1016/j.jacep.2015.10.003. Epub 2015 Nov 10.

Cardiac magnetic resonance with implanted monitor.

Ionescu B, Giacopelli D, Pappone C.

Acta Cardiol. 2015 Oct;70(5):601-2. doi: 10.2143/AC.70.5.3110524. No abstract available.

Catheter ablation of atrial fibrillation in patients with diabetes mellitus: a systematic review and meta-analysis.

Anselmino M, Matta M, D’ascenzo F, Pappone C, Santinelli V, Bunch TJ, Neumann T, Schilling RJ, Hunter RJ, Noelker G, Fiala M, Frontera A, Thomas G, Katritsis D, Jais P, Weerasooriya R, Kalman JM, Gaita F.

Europace. 2015 Oct;17(10):1518-25. doi: 10.1093/europace/euv214. Review.

An update on atrial fibrillation in 2014: From pathophysiology to treatment.

Ferrari R, Bertini M, Blomstrom-Lundqvist C, Dobrev D, Kirchhof P, Pappone C, Ravens U, Tamargo J, Tavazzi L, Vicedomini GG.

Int J Cardiol. 2016 Jan 15;203:22-9. doi: 10.1016/j.ijcard.2015.10.089. Epub 2015 Oct 18. Review.

Epicardial mapping and ablation of the right ventricle substrate during flecainide testing in Brugada syndrome.

Gonzalez-Melchor L, Brugada J, Martinez-Sande JL, Garcia-Seara J, Fernandez-Lopez JA, Pappone C, Gonzalez-Juanatey JR.

HeartRhythm Case Rep. 2015 Sep 30;2(1):52-56. doi: 10.1016/j.hrcr.2015.09.005. eCollection 2016 Jan. No abstract available.

Electrophysiology testing and catheter ablation are helpful when evaluating asymptomatic patients with Wolff-Parkinson-White pattern: the pro perspective.

Pappone C, Santinelli V.

Card Electrophysiol Clin. 2015 Sep;7(3):371-6. doi: 10.1016/j.ccep.2015.05.001. Epub 2015 Jul 10. Review.

Brugada Syndrome Phenotype Elimination by Epicardial Substrate Ablation.

Brugada J, Pappone C, Berruezo A, Vicedomini G, Manguso F, Ciconte G, Giannelli L, Santinelli V.

Circ Arrhythm Electrophysiol. 2015 Dec;8(6):1373-81. doi: 10.1161/CIRCEP.115.003220. Epub 2015 Aug 19.

Ventricular fibrillation in lone atrial fibrillation as clinical manifestation of latent Brugada syndrome: Usefulness of flecainide testing.

Pappone C, Vicedomini G, Petretta A, Giannelli L, Cuko A, Santinelli V.

HeartRhythm Case Rep. 2015 Jun 6;1(5):285-289. doi: 10.1016/j.hrcr.2015.02.013. eCollection 2015 Sep. No abstract available.

Response to letter regarding article, “Wolff-Parkinson-White syndrome in the era of catheter ablation: insights from a registry study of 2169 patients”.

Pappone C, Vicedomini G, Manguso F, Saviano M, Baldi M, Pappone A, Ciaccio C, Giannelli L, Ionescu B, Petretta A, Vitale R, Cuko A, Calovic Z, Fundaliotis A, Moscatiello M, Tavazzi L, Santinelli V.

Circulation. 2015 May 19;131(20):e499. doi: 10.1161/CIRCULATIONAHA.114.014534. No abstract available.

Influence of Age and Gender on Complications of Catheter Ablation for Atrial Fibrillation.

Stabile G, Bertaglia E, Pappone C, Themistoclakis S, Tondo C, Zorzi A, Anselmino M.

J Atr Fibrillation. 2015 Apr 30;7(6):1197. doi: 10.4022/jafib.1197. eCollection 2015 Apr-May.

The use of adenosine and adenosine triphosphate testing in the diagnosis, risk stratification and management of patients with syncope: current evidence and future perspectives.

Fragakis N, Antoniadis AP, Saviano M, Vassilikos V, Pappone C.

Int J Cardiol. 2015 Mar 15;183:267-73. doi: 10.1016/j.ijcard.2015.01.089. Epub 2015 Jan 30. Review.

Response to letter regarding “Catheter ablation of atrial fibrillation in patients with left ventricular systolic dysfunction: a systematic review and meta-analysis”.

Anselmino M, Matta M, D’Ascenzo F, Bunch TJ, Schilling RJ, Hunter RJ, Pappone C, Neumann T, Noelker G, Fiala M, Bertaglia E, Frontera A, Duncan E, Nalliah C, Jais P, Weerasooriya R, Kalman JM, Gaita F.

Circ Arrhythm Electrophysiol. 2015 Feb;8(1):246. doi: 10.1161/CIRCEP.115.002697. No abstract available.

Improving cardiac resynchronization therapy response with multipoint left ventricular pacing: Twelve-month follow-up study.

Pappone C, Ćalović Ž, Vicedomini G, Cuko A, McSpadden LC, Ryu K, Jordan CD, Romano E, Baldi M, Saviano M, Pappone A, Vitale R, Catalano C, Ciaccio C, Giannelli L, Ionescu B, Petretta A, Fragakis N, Fundaliotis A, Tavazzi L, Santinelli V.

Heart Rhythm. 2015 Jun;12(6):1250-8. doi: 10.1016/j.hrthm.2015.02.008. Epub 2015 Feb 9.

Catheter ablation of atrial fibrillation in patients with left ventricular systolic dysfunction: a systematic review and meta-analysis.

Anselmino M, Matta M, D’Ascenzo F, Bunch TJ, Schilling RJ, Hunter RJ, Pappone C, Neumann T, Noelker G, Fiala M, Bertaglia E, Frontera A, Duncan E, Nalliah C, Jais P, Weerasooriya R, Kalman JM, Gaita F.

Circ Arrhythm Electrophysiol. 2014 Dec;7(6):1011-8. doi: 10.1161/CIRCEP.114.001938. Epub 2014 Sep 28. Review.

Multipoint left ventricular pacing in a single coronary sinus branch improves mid-term echocardiographic and clinical response to cardiac resynchronization therapy.

Pappone C, Ćalović Ž, Vicedomini G, Cuko A, McSpadden LC, Ryu K, Romano E, Baldi M, Saviano M, Pappone A, Ciaccio C, Giannelli L, Ionescu B, Petretta A, Vitale R, Fundaliotis A, Tavazzi L, Santinelli V.

J Cardiovasc Electrophysiol. 2015 Jan;26(1):58-63. doi: 10.1111/jce.12513. Epub 2014 Sep 19.

Low incidence of permanent complications during catheter ablation for atrial fibrillation using open-irrigated catheters: a multicentre registry.

Stabile G, Bertaglia E, Pappone A, Themistoclakis S, Tondo C, Calzolari V, Bottoni N, Arena G, Rebellato L, Del Greco M, De Simone A, Corò L, Avella A, Anselmino M, Pappone C.

Europace. 2014 Aug;16(8):1154-9. doi: 10.1093/europace/euu002.

Wolff-Parkinson-White syndrome in the era of catheter ablation: insights from a registry study of 2169 patients.

Pappone C, Vicedomini G, Manguso F, Saviano M, Baldi M, Pappone A, Ciaccio C, Giannelli L, Ionescu B, Petretta A, Vitale R, Cuko A, Calovic Z, Fundaliotis A, Moscatiello M, Tavazzi L, Santinelli V.

Circulation. 2014 Sep 2;130(10):811-9. doi: 10.1161/CIRCULATIONAHA.114.011154. Epub 2014 Jul 22.

The Unique MediGuide Technology For CRT Lead Placement And Catheter Ablation.

Pappone C, Berto MB, Santinelli V.

J Atr Fibrillation. 2014 Jun 30;7(1):1072. doi: 10.4022/jafib.1072. eCollection 2014 Jun-Jul. Review.

Prospective European survey on atrial fibrillation ablation: clinical characteristics of patients and ablation strategies used in different countries.

Themistoclakis S, Raviele A, China P, Pappone C, De Ponti R, Revishvili A, Aliot E, Kuck KH, Hoff PI, Shah D, Almendral J, Manolis AS, Chierchia GB, Oto A, Vatasescu RG, Sinkovec M, Cappato R; Atrial Fibrillation Survey Investigators.

J Cardiovasc Electrophysiol. 2014 Oct;25(10):1074-81. doi: 10.1111/jce.12462. Epub 2014 Jul 8.

Endurance Sport Activity and Risk of Atrial Fibrillation – Epidemiology, Proposed Mechanisms and Management.

Fragakis N, Vicedomini G, Pappone C.

Arrhythm Electrophysiol Rev. 2014 May;3(1):15-9. doi: 10.15420/aer.2011.3.1.15. Epub 2014 May 30.

The atrial fibrillation ablation pilot study: a European Survey on Methodology and results of catheter ablation for atrial fibrillation conducted by the European Heart Rhythm Association.

Arbelo E, Brugada J, Hindricks G, Maggioni AP, Tavazzi L, Vardas P, Laroche C, Anselme F, Inama G, Jais P, Kalarus Z, Kautzner J, Lewalter T, Mairesse GH, Perez-Villacastin J, Riahi S, Taborsky M, Theodorakis G, Trines SA; Atrial Fibrillation Ablation Pilot Study Investigators.

Eur Heart J. 2014 Jun 7;35(22):1466-78. doi: 10.1093/eurheartj/ehu001. Epub 2014 Jan 31.

Multipoint left ventricular pacing improves acute hemodynamic response assessed with pressure-volume loops in cardiac resynchronization therapy patients.

Pappone C, Ćalović Ž, Vicedomini G, Cuko A, McSpadden LC, Ryu K, Romano E, Saviano M, Baldi M, Pappone A, Ciaccio C, Giannelli L, Ionescu B, Petretta A, Vitale R, Fundaliotis A, Tavazzi L, Santinelli V.

Heart Rhythm. 2014 Mar;11(3):394-401. doi: 10.1016/j.hrthm.2013.11.023. Epub 2013 Nov 28.

Atrio-Esophageal Fistula After AF Ablation: Pathophysiology, Prevention &Treatment.

Pappone C, Vicedomini G, Santinelli V.

J Atr Fibrillation. 2013 Oct 31;6(3):860. doi: 10.4022/jafib.860. eCollection 2013 Oct-Nov. Review.

Cardiac resynchronization therapy: implant rates, temporal trends and relationships with heart failure epidemiology.

Boriani G, Berti E, Belotti LM, Biffi M, Carboni A, Bandini A, Casali E, Tomasi C, Toselli T, Baraldi P, Bottoni N, Barbato G, Sassone B; RERAI (Registry of Emilia Romagna on Arrhythmia Interventions) Investigators.

J Cardiovasc Med (Hagerstown). 2014 Feb;15(2):147-54. doi: 10.2459/JCM.0b013e3283638d90.

Updated national multicenter registry on procedural safety of catheter ablation for atrial fibrillation.

Bertaglia E, Stabile G, Pappone A, Themistoclakis S, Tondo C, De Sanctis V, Soldati E, Tritto M, Solimene F, Grimaldi M, Zoppo F, Pandozi C, Augello G, Calò L, Pappone C.

J Cardiovasc Electrophysiol. 2013 Oct;24(10):1069-74. doi: 10.1111/jce.12194. Epub 2013 Jun 25.

Genetics can contribute to the prognosis of Brugada syndrome: a pilot model for risk stratification.

Sommariva E, Pappone C, Martinelli Boneschi F, Di Resta C, Rosaria Carbone M, Salvi E, Vergara P, Sala S, Cusi D, Ferrari M, Benedetti S.

Eur J Hum Genet. 2013 Sep;21(9):911-7. doi: 10.1038/ejhg.2012.289. Epub 2013 Jan 16.

Transcatheter renal sympathetic ablation for resistant hypertension: in vivo insights in humans from optical coherence tomography.

Ierna S, Biondi-Zoccai G, Bachis C, Occhipinti M, Di Vito L, Ricciardi A, Pappone C, Prati F.

Int J Cardiol. 2013 May 10;165(2):e35-7. doi: 10.1016/j.ijcard.2012.10.056. Epub 2012 Nov 17. No abstract available.

Venice Chart international consensus document on atrial fibrillation ablation: 2011 update.

Raviele A, Natale A, Calkins H, Camm JA, Cappato R, Ann Chen S, Connolly SJ, Damiano R Jr, DE Ponti R, Edgerton JR, Haïssaguerre M, Hindricks G, Ho SY, Jalife J, Kirchhof P, Kottkamp H, Kuck KH, Marchlinski FE, Packer DL, Pappone C, Prystowsky E, Reddy VK, Themistoclakis S, Verma A, Wilber DJ, Willems S; Venice Chart.

J Cardiovasc Electrophysiol. 2012 Aug;23(8):890-923. doi: 10.1111/j.1540-8167.2012.02381.x. Review. No abstract available.

Asymptomatic Wolff-Parkinson-White Syndrome Should be Ablated.

Pappone C, Santinelli V.

Card Electrophysiol Clin. 2012 Sep;4(3):281-5. doi: 10.1016/j.ccep.2012.06.006.

Post Ablation Left Atrial Tachycardia: Understanding Mechanism, Prevention and Treatment.

Pappone C, Santinelli V.

J Atr Fibrillation. 2012 Aug 20;5(2):525. doi: 10.4022/jafib.525. eCollection 2012 Aug-Sep. Review.

ESC-EURObservational Research Programme: the Atrial Fibrillation Ablation Pilot Study, conducted by the European Heart Rhythm Association.

Arbelo E, Brugada J, Hindricks G, Maggioni A, Tavazzi L, Vardas P, Anselme F, Inama G, Jais P, Kalarus Z, Kautzner J, Lewalter T, Mairesse G, Perez-Villacastin J, Riahi S, Taborsky M, Theodorakis G, Trines S; Atrial Fibrillation Ablation Pilot Study Investigators.

Europace. 2012 Aug;14(8):1094-103. Epub 2012 May 24.

Atrial fibrillation ablation.

Pappone C, Santinelli V.

Rev Esp Cardiol (Engl Ed). 2012 Jun;65(6):560-9. doi: 10.1016/j.recesp.2011.12.023. Epub 2012 Apr 26.

2012 HRS/EHRA/ECAS Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation: recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design.

Calkins H, Kuck KH, Cappato R, Brugada J, Camm AJ, Chen SA, Crijns HJ, Damiano RJ Jr, Davies DW, DiMarco J, Edgerton J, Ellenbogen K, Ezekowitz MD, Haines DE, Haissaguerre M, Hindricks G, Iesaka Y, Jackman W, Jalife J, Jais P, Kalman J, Keane D, Kim YH, Kirchhof P, Klein G, Kottkamp H, Kumagai K, Lindsay BD, Mansour M, Marchlinski FE, McCarthy PM, Mont JL, Morady F, Nademanee K, Nakagawa H, Natale A, Nattel S, Packer DL, Pappone C, Prystowsky E, Raviele A, Reddy V, Ruskin JN, Shemin RJ, Tsao HM, Wilber D.

Europace. 2012 Apr;14(4):528-606. doi: 10.1093/europace/eus027. Epub 2012 Mar 1. No abstract available.

2012 HRS/EHRA/ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design: a report of the Heart Rhythm Society (HRS) Task Force on Catheter and Surgical Ablation of Atrial Fibrillation. Developed in partnership with the European Heart Rhythm Association (EHRA), a registered branch of the European Society of Cardiology (ESC) and the European Cardiac Arrhythmia Society (ECAS); and in collaboration with the American College of Cardiology (ACC), American Heart Association (AHA), the Asia Pacific Heart Rhythm Society (APHRS), and the Society of Thoracic Surgeons (STS). Endorsed by the governing bodies of the American College of Cardiology Foundation, the American Heart Association, the European Cardiac Arrhythmia Society, the European Heart Rhythm Association, the Society of Thoracic Surgeons, the Asia Pacific Heart Rhythm Society, and the Heart Rhythm Society.

Calkins H, Kuck KH, Cappato R, Brugada J, Camm AJ, Chen SA, Crijns HJ, Damiano RJ Jr, Davies DW, DiMarco J, Edgerton J, Ellenbogen K, Ezekowitz MD, Haines DE, Haissaguerre M, Hindricks G, Iesaka Y, Jackman W, Jalife J, Jais P, Kalman J, Keane D, Kim YH, Kirchhof P, Klein G, Kottkamp H, Kumagai K, Lindsay BD, Mansour M, Marchlinski FE, McCarthy PM, Mont JL, Morady F, Nademanee K, Nakagawa H, Natale A, Nattel S, Packer DL, Pappone C, Prystowsky E, Raviele A, Reddy V, Ruskin JN, Shemin RJ, Tsao HM, Wilber D; Heart Rhythm Society Task Force on Catheter and Surgical Ablation of Atrial Fibrillation.

Heart Rhythm. 2012 Apr;9(4):632-696.e21. doi: 10.1016/j.hrthm.2011.12.016. Epub 2012 Mar 1. No abstract available.

2012 HRS/EHRA/ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design.

Calkins H, Kuck KH, Cappato R, Brugada J, Camm AJ, Chen SA, Crijns HJ, Damiano RJ Jr, Davies DW, DiMarco J, Edgerton J, Ellenbogen K, Ezekowitz MD, Haines DE, Haissaguerre M, Hindricks G, Iesaka Y, Jackman W, Jalife J, Jais P, Kalman J, Keane D, Kim YH, Kirchhof P, Klein G, Kottkamp H, Kumagai K, Lindsay BD, Mansour M, Marchlinski FE, McCarthy PM, Mont JL, Morady F, Nademanee K, Nakagawa H, Natale A, Nattel S, Packer DL, Pappone C, Prystowsky E, Raviele A, Reddy V, Ruskin JN, Shemin RJ, Tsao HM, Wilber D.

J Interv Card Electrophysiol. 2012 Mar;33(2):171-257. doi: 10.1007/s10840-012-9672-7. Review.

Risk of malignant arrhythmias in initially symptomatic patients with Wolff-Parkinson-White syndrome: results of a prospective long-term electrophysiological follow-up study.

Pappone C, Vicedomini G, Manguso F, Baldi M, Pappone A, Petretta A, Vitale R, Saviano M, Ciaccio C, Giannelli L, Calovic Z, Tavazzi L, Santinelli V.

Circulation. 2012 Feb 7;125(5):661-8. doi: 10.1161/CIRCULATIONAHA.111.065722. Epub 2012 Jan 3.

Risk stratification in Brugada syndrome: results of the PRELUDE (PRogrammed ELectrical stimUlation preDictive valuE) registry.

Priori SG, Gasparini M, Napolitano C, Della Bella P, Ottonelli AG, Sassone B, Giordano U, Pappone C, Mascioli G, Rossetti G, De Nardis R, Colombo M.

J Am Coll Cardiol. 2012 Jan 3;59(1):37-45. doi: 10.1016/j.jacc.2011.08.064.

Radiofrequency catheter ablation and antiarrhythmic drug therapy: a prospective, randomized, 4-year follow-up trial: the APAF study.

Pappone C, Vicedomini G, Augello G, Manguso F, Saviano M, Baldi M, Petretta A, Giannelli L, Calovic Z, Guluta V, Tavazzi L, Santinelli V.

Circ Arrhythm Electrophysiol. 2011 Dec;4(6):808-14. doi: 10.1161/CIRCEP.111.966408. Epub 2011 Sep 23.

A Brugada syndrome mutation (p.S216L) and its modulation by p.H558R polymorphism: standard and dynamic characterization.

Marangoni S, Di Resta C, Rocchetti M, Barile L, Rizzetto R, Summa A, Severi S, Sommariva E, Pappone C, Ferrari M, Benedetti S, Zaza A.

Cardiovasc Res. 2011 Sep 1;91(4):606-16. doi: 10.1093/cvr/cvr142. Epub 2011 Jun 24.

Device-based left atrial appendage closure.

Pappone C, Vicedomini G, Cremonesi A, Zuffada F, Santinelli V.

Circ Arrhythm Electrophysiol. 2011 Jun;4(3):418-9. doi: 10.1161/CIRCEP.111.962423. No abstract available.

Magnetically controllable gastrointestinal steering of video capsules.

Carpi F, Kastelein N, Talcott M, Pappone C.

IEEE Trans Biomed Eng. 2011 Feb;58(2):231-4. doi: 10.1109/TBME.2010.2087332. Epub 2010 Oct 14.

Irrigated-tip magnetic catheter ablation of AF: a long-term prospective study in 130 patients.

Pappone C, Vicedomini G, Frigoli E, Giannelli L, Ciaccio C, Baldi M, Zuffada F, Saviano M, Pappone A, Crisà S, Petretta A, Santinelli V.

Heart Rhythm. 2011 Jan;8(1):8-15. doi: 10.1016/j.hrthm.2010.09.074. Epub 2010 Sep 29.

Cardiac electrophysiology in diabetes.

Pappone C, Santinelli V.

Minerva Cardioangiol. 2010 Apr;58(2):269-76.

Comparison of antiarrhythmic drug therapy and radiofrequency catheter ablation in patients with paroxysmal atrial fibrillation: a randomized controlled trial.

Wilber DJ, Pappone C, Neuzil P, De Paola A, Marchlinski F, Natale A, Macle L, Daoud EG, Calkins H, Hall B, Reddy V, Augello G, Reynolds MR, Vinekar C, Liu CY, Berry SM, Berry DA; ThermoCool AF Trial Investigators.

JAMA. 2010 Jan 27;303(4):333-40. doi: 10.1001/jama.2009.2029.

Pulmonary vein isolation after circumferential pulmonary vein ablation: comparison between Lasso and three-dimensional electroanatomical assessment of complete electrical disconnection.

Augello G, Vicedomini G, Saviano M, Crisa S, Mazzone P, Ornago O, Zuffada F, Santinelli V, Pappone C.

Heart Rhythm. 2009 Dec;6(12):1706-13. doi: 10.1016/j.hrthm.2009.09.008. Epub 2009 Sep 6.

Intrathoracic and ventricular impedances are associated with changes in ventricular volume in patients receiving defibrillators for CRT.

Maines M, Landolina M, Lunati M, Lonardi G, Pappone A, Proclemer A, Zanotto G, Santini M, Varbaro A, Vimercati M, Valsecchi S; Italian Clinical Service Optivol-CRT Group.

Pacing Clin Electrophysiol. 2010 Jan;33(1):64-73. doi: 10.1111/j.1540-8159.2009.02579.x. Epub 2009 Oct 10.

Asymptomatic ventricular preexcitation: a long-term prospective follow-up study of 293 adult patients.

Santinelli V, Radinovic A, Manguso F, Vicedomini G, Ciconte G, Gulletta S, Paglino G, Sacchi S, Sala S, Ciaccio C, Pappone C.

Circ Arrhythm Electrophysiol. 2009 Apr;2(2):102-7. doi: 10.1161/CIRCEP.108.827550. Epub 2009 Feb 13.

Atrial fibrillation ablation: how far have we come?

Pappone C, Santinelli V.

Rev Esp Cardiol. 2009 Oct;62(10):1087-91. English, Spanish. No abstract available.

Stereotaxis Niobe magnetic navigation system for endocardial catheter ablation and gastrointestinal capsule endoscopy.

Carpi F, Pappone C.

Expert Rev Med Devices. 2009 Sep;6(5):487-98. doi: 10.1586/erd.09.32.

New-onset atrial fibrillation as first clinical manifestation of latent Brugada syndrome: prevalence and clinical significance.

Pappone C, Radinovic A, Manguso F, Vicedomini G, Sala S, Sacco FM, Ciconte G, Saviano M, Ferrari M, Sommariva E, Sacchi S, Ciaccio C, Kallergis EM, Santinelli V.

Eur Heart J. 2009 Dec;30(24):2985-92. doi: 10.1093/eurheartj/ehp326.

Product-experience reporting on endocardial defibrillation leads: a 4-year national perspective.

Padeletti L, Pappone C, Curnis A, Zanotto G, Calò L, Ricciardi G, Pieragnoli P, Dondina C, Raciti G, Michelucci A.

Expert Rev Med Devices. 2009 Jul;6(4):383-8. doi: 10.1586/erd.09.22.

Monitoring intrathoracic impedance with an implantable defibrillator reduces hospitalizations in patients with heart failure.

Catanzariti D, Lunati M, Landolina M, Zanotto G, Lonardi G, Iacopino S, Oliva F, Perego GB, Varbaro A, Denaro A, Valsecchi S, Vergara G; Italian Clinical Service Optivol-CRT Group.

Pacing Clin Electrophysiol. 2009 Mar;32(3):363-70. doi: 10.1111/j.1540-8159.2008.02245.x.

Magnetic maneuvering of endoscopic capsules by means of a robotic navigation system.

Carpi F, Pappone C.

IEEE Trans Biomed Eng. 2009 May;56(5):1482-90. doi: 10.1109/TBME.2009.2013336. Epub 2009 Jan 23.

The natural history of asymptomatic ventricular pre-excitation a long-term prospective follow-up study of 184 asymptomatic children.

Santinelli V, Radinovic A, Manguso F, Vicedomini G, Gulletta S, Paglino G, Mazzone P, Ciconte G, Sacchi S, Sala S, Pappone C.

J Am Coll Cardiol. 2009 Jan 20;53(3):275-80. doi: 10.1016/j.jacc.2008.09.037.

Atrial fibrillation progression and management: a 5-year prospective follow-up study.

Pappone C, Radinovic A, Manguso F, Vicedomini G, Ciconte G, Sacchi S, Mazzone P, Paglino G, Gulletta S, Sala S, Santinelli V.

Heart Rhythm. 2008 Nov;5(11):1501-7. doi: 10.1016/j.hrthm.2008.08.011. Epub 2008 Aug 17.

Implantable CRT device diagnostics identify patients with increased risk for heart failure hospitalization.

Perego GB, Landolina M, Vergara G, Lunati M, Zanotto G, Pappone A, Lonardi G, Speca G, Iacopino S, Varbaro A, Sarkar S, Hettrick DA, Denaro A; Optivol-CRT Clinical Service Observational Group.

J Interv Card Electrophysiol. 2008 Dec;23(3):235-42. doi: 10.1007/s10840-008-9303-5. Epub 2008 Sep 23.

Magnetic robotic manoeuvring of gastrointestinal video capsules: preliminary phantom tests.

Carpi F, Pappone C.

Biomed Pharmacother. 2008 Oct;62(8):546-9. doi: 10.1016/j.biopha.2008.07.057. Epub 2008 Aug 6.

Safety and efficacy of remote magnetic ablation for atrial fibrillation.

Pappone C, Santinelli V.

J Am Coll Cardiol. 2008 Apr 22;51(16):1614-5; author reply 1615-6. doi: 10.1016/j.jacc.2007.11.078. No abstract available.

Sudden death and ventricular preexcitation: is it necessary to treat the asymptomatic patients?

Pappone C, Radinovic A, Santinelli V.

Curr Pharm Des. 2008;14(8):762-5. Review.

Follow-up of CRT-ICD: implications for the use of remote follow-up systems. Data from the InSync ICD Italian Registry.

Lunati M, Gasparini M, Santini M, Landolina M, Perego GB, Pappone C, Marzegalli M, Argiolas C, Murthy A, Valsecchi S; InSync ICD Italian Registry Investigators.

Pacing Clin Electrophysiol. 2008 Jan;31(1):38-46. doi: 10.1111/j.1540-8159.2007.00923.x.

Remote ablation of accessory pathways.

Pappone C, Santinelli V.

Eur Heart J. 2008 Feb;29(3):422. Epub 2007 Nov 24. No abstract available.

Robotic and magnetic navigation for atrial fibrillation ablation. How and why?

Pappone C, Augello G, Gugliotta F, Santinelli V.

Expert Rev Med Devices. 2007 Nov;4(6):885-94. Review.

HRS/EHRA/ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: recommendations for personnel, policy, procedures and follow-up. A report of the Heart Rhythm Society (HRS) Task Force on Catheter and Surgical Ablation of Atrial Fibrillation developed in partnership with the European Heart Rhythm Association (EHRA) and the European Cardiac Arrhythmia Society (ECAS); in collaboration with the American College of Cardiology (ACC), American Heart Association (AHA), and the Society of Thoracic Surgeons (STS). Endorsed and approved by the governing bodies of the American College of Cardiology, the American Heart Association, the European Cardiac Arrhythmia Society, the European Heart Rhythm Association, the Society of Thoracic Surgeons, and the Heart Rhythm Society.

Calkins H, Brugada J, Packer DL, Cappato R, Chen SA, Crijns HJ, Damiano RJ Jr, Davies DW, Haines DE, Haissaguerre M, Iesaka Y, Jackman W, Jais P, Kottkamp H, Kuck KH, Lindsay BD, Marchlinski FE, McCarthy PM, Mont JL, Morady F, Nademanee K, Natale A, Pappone C, Prystowsky E, Raviele A, Ruskin JN, Shemin RJ; Heart Rhythm Society; European Heart Rhythm Association; European Cardiac Arrhythmia Society; American College of Cardiology; American Heart Association; Society of Thoracic Surgeons.

Europace. 2007 Jun;9(6):335-79. No abstract available. Erratum in: Europace. 2009 Jan;11(1):132.

HRS/EHRA/ECAS expert Consensus Statement on catheter and surgical ablation of atrial fibrillation: recommendations for personnel, policy, procedures and follow-up. A report of the Heart Rhythm Society (HRS) Task Force on catheter and surgical ablation of atrial fibrillation.

European Heart Rhythm Association (EHRA); European Cardiac Arrhythmia Scoiety (ECAS); American College of Cardiology (ACC); American Heart Association (AHA); Society of Thoracic Surgeons (STS), Calkins H, Brugada J, Packer DL, Cappato R, Chen SA, Crijns HJ, Damiano RJ Jr, Davies DW, Haines DE, Haissaguerre M, Iesaka Y, Jackman W, Jais P, Kottkamp H, Kuck KH, Lindsay BD, Marchlinski FE, McCarthy PM, Mont JL, Morady F, Nademanee K, Natale A, Pappone C, Prystowsky E, Raviele A, Ruskin JN, Shemin RJ.

Heart Rhythm. 2007 Jun;4(6):816-61. Epub 2007 Apr 30. Review. No abstract available. Erratum in: Heart Rhythm. 2009 Jan;6(1):148.

Venice Chart international consensus document on atrial fibrillation ablation.

Natale A, Raviele A, Arentz T, Calkins H, Chen SA, Haïssaguerre M, Hindricks G, Ho Y, Kuck KH, Marchlinski F, Napolitano C, Packer D, Pappone C, Prystowsky EN, Schilling R, Shah D, Themistoclakis S, Verma A.

J Cardiovasc Electrophysiol. 2007 May;18(5):560-80. No abstract available.

Mapping and ablation: a worldwide perspective.

Pappone C, Santinelli V.

J Interv Card Electrophysiol. 2006 Dec;17(3):195-8. Epub 2007 Apr 6. Review.

A randomized trial of circumferential pulmonary vein ablation versus antiarrhythmic drug therapy in paroxysmal atrial fibrillation: the APAF Study.

Pappone C, Augello G, Sala S, Gugliotta F, Vicedomini G, Gulletta S, Paglino G, Mazzone P, Sora N, Greiss I, Santagostino A, LiVolsi L, Pappone N, Radinovic A, Manguso F, Santinelli V.

J Am Coll Cardiol. 2006 Dec 5;48(11):2340-7. Epub 2006 Oct 16.

Electroanatomic remodeling of the left atrium in patients undergoing repeat pulmonary vein ablation: mechanistic insights and implications for ablation.

Mesas CE, Augello G, Lang CC, Gugliotta F, Vicedomini G, Sora N, De Paola AA, Pappone C.

J Cardiovasc Electrophysiol. 2006 Dec;17(12):1279-85. Epub 2006 Nov 1.

Ablation of atrial fibrillation.

Pappone C, Santinelli V.

Curr Cardiol Rep. 2006 Sep;8(5):343-6. Review.

How to perform encircling ablation of the left atrium.

Pappone C, Santinelli V.

Heart Rhythm. 2006 Sep;3(9):1105-9. Epub 2006 Mar 13. Review. No abstract available.

Robotic magnetic navigation for atrial fibrillation ablation.

Pappone C, Vicedomini G, Manguso F, Gugliotta F, Mazzone P, Gulletta S, Sora N, Sala S, Marzi A, Augello G, Livolsi L, Santagostino A, Santinelli V.

J Am Coll Cardiol. 2006 Apr 4;47(7):1390-400. Epub 2006 Mar 15.

Multielectrode basket catheter: a new tool for curing atrial fibrillation?

Pappone C, Santinelli V.

Heart Rhythm. 2006 Apr;3(4):385-6. No abstract available.

Circumferential pulmonary-vein ablation for chronic atrial fibrillation.

Oral H, Pappone C, Chugh A, Good E, Bogun F, Pelosi F Jr, Bates ER, Lehmann MH, Vicedomini G, Augello G, Agricola E, Sala S, Santinelli V, Morady F.

N Engl J Med. 2006 Mar 2;354(9):934-41.

Role of regional mechanical dyssynchrony as a determinant of functional mitral regurgitation in patients with left ventricular systolic dysfunction.

Agricola E, Oppizzi M, Galderisi M, Pisani M, Meris A, Pappone C, Margonato A.

Heart. 2006 Oct;92(10):1390-5. Epub 2006 Jan 31.

Endocardial impedance mapping during circumferential pulmonary vein ablation of atrial fibrillation differentiates between atrial and venous tissue.

Lang CC, Gugliotta F, Santinelli V, Mesas C, Tomita T, Vicedomini G, Augello G, Gulletta S, Mazzone P, De Cobelli F, Del Maschio A, Pappone C.

Heart Rhythm. 2006 Feb;3(2):171-8.

Atrial fibrillation ablation: state of the art.

Pappone C, Santinelli V.

Am J Cardiol. 2005 Dec 19;96(12A):59L-64L. Epub 2005 Oct 5. Review.

Electrical signals applied during the absolute refractory period: an investigational treatment for advanced heart failure in patients with normal QRS duration.

Lawo T, Borggrefe M, Butter C, Hindricks G, Schmidinger H, Mika Y, Burkhoff D, Pappone C, Sabbah HN.

J Am Coll Cardiol. 2005 Dec 20;46(12):2229-36. Review.

Atrial fibrillation ablation: a realistic alternative to pharmacologic therapy.

Pappone C, Santinelli V.

Nat Clin Pract Cardiovasc Med. 2005 Dec;2(12):608-9. No abstract available.

Myocyte changes and their left atrial distribution in patients with chronic atrial fibrillation related to mitral valve disease.

Corradi D, Callegari S, Benussi S, Maestri R, Pastori P, Nascimbene S, Bosio S, Dorigo E, Grassani C, Rusconi R, Vettori MV, Alinovi R, Astorri E, Pappone C, Alfieri O.

Hum Pathol. 2005 Oct;36(10):1080-9.

Should catheter ablation be performed in asymptomatic patients with Wolff-Parkinson-White syndrome? Catheter ablation should be performed in asymptomatic patients with Wolff-Parkinson-White syndrome.

Pappone C, Santinelli V.

Circulation. 2005 Oct 4;112(14):2207-15; discussion 2216. No abstract available.

Surgical ablation of atrial fibrillation with a novel bipolar radiofrequency device.

Benussi S, Nascimbene S, Calori G, Denti P, Ziskind Z, Kassem S, La Canna G, Pappone C, Alfieri O.

J Thorac Cardiovasc Surg. 2005 Aug;130(2):491-7.

Towards a unified strategy for atrial fibrillation ablation?

Pappone C, Santinelli V.

Eur Heart J. 2005 Aug;26(16):1687-8; author reply 1688. Epub 2005 Jul 13. No abstract available.

Percutaneous left atrial appendage transcatheter occlusion (PLAATO system) to prevent stroke in high-risk patients with non-rheumatic atrial fibrillation: results from the international multi-center feasibility trials.

Ostermayer SH, Reisman M, Kramer PH, Matthews RV, Gray WA, Block PC, Omran H, Bartorelli AL, Della Bella P, Di Mario C, Pappone C, Casale PN, Moses JW, Poppas A, Williams DO, Meier B, Skanes A, Teirstein PS, Lesh MD, Nakai T, Bayard Y, Billinger K, Trepels T, Krumsdorf U, Sievert H.

J Am Coll Cardiol. 2005 Jul 5;46(1):9-14.

The effect of concomitant radiofrequency ablation and surgical technique (repair versus replacement) on release of cardiac biomarkers during mitral valve surgery.

Zangrillo A, Crescenzi G, Landoni G, Benussi S, Crivellari M, Pappalardo F, Dorigo E, Pappone C, Alfieri O.

Anesth Analg. 2005 Jul;101(1):24-9, table of contents.

Atrial fibrillation ablation.

Pappone C, Augello G, Santinelli V.

Ital Heart J. 2005 Mar;6(3):190-9. Review.

Segmental pulmonary vein isolation versus the circumferential approach: is the tide turning?

Pappone C, Santinelli V.

Heart Rhythm. 2004 Sep;1(3):326-8. No abstract available.

Transcatheter radiofrequency ablation of atrial fibrillation in patients with mitral valve prostheses and enlarged atria: safety, feasibility, and efficacy.

Lang CC, Santinelli V, Augello G, Ferro A, Gugliotta F, Gulletta S, Vicedomini G, Mesas C, Paglino G, Sala S, Sora N, Mazzone P, Manguso F, Pappone C.

J Am Coll Cardiol. 2005 Mar 15;45(6):868-72.

A 20-joule electrical cardioversion applied directly to the heart elevates troponin I by at least 1.5 ng.mL-1.

Zangrillo A, Landoni G, Crescenzi G, Scandroglio AM, Calabrò MG, Mantovani L, Franco A, Pappone C.

Can J Anaesth. 2005 Mar;52(3):336-7. No abstract available.

Percutaneous mitral valve repair: an attractive perspective and an opportunity for teamwork.

Alfieri O, Maisano F, Colombo A, Pappone C, La Canna G, Zangrillo A.

Ital Heart J. 2004 Oct;5(10):723-6. No abstract available.

Prevention of iatrogenic atrial tachycardia after ablation of atrial fibrillation: a prospective randomized study comparing circumferential pulmonary vein ablation with a modified approach.

Pappone C, Manguso F, Vicedomini G, Gugliotta F, Santinelli O, Ferro A, Gulletta S, Sala S, Sora N, Paglino G, Augello G, Agricola E, Zangrillo A, Alfieri O, Santinelli V.

Circulation. 2004 Nov 9;110(19):3036-42. Epub 2004 Nov 1.

The who, what, why, and how-to guide for circumferential pulmonary vein ablation.

Pappone C, Santinelli V.

J Cardiovasc Electrophysiol. 2004 Oct;15(10):1226-30. No abstract available.

Prevention of atrial fibrillation: how important is transseptal atrial conduction in humans?

Pappone C, Santinelli V.

J Cardiovasc Electrophysiol. 2004 Oct;15(10):1118-9. No abstract available.

Radiofrequency ablation in children with asymptomatic Wolff-Parkinson-White syndrome.

Pappone C, Manguso F, Santinelli R, Vicedomini G, Sala S, Paglino G, Mazzone P, Lang CC, Gulletta S, Augello G, Santinelli O, Santinelli V.

N Engl J Med. 2004 Sep 16;351(12):1197-205.

Left atrial tachycardia after circumferential pulmonary vein ablation for atrial fibrillation: electroanatomic characterization and treatment.

Mesas CE, Pappone C, Lang CC, Gugliotta F, Tomita T, Vicedomini G, Sala S, Paglino G, Gulletta S, Ferro A, Santinelli V.

J Am Coll Cardiol. 2004 Sep 1;44(5):1071-9.

Regional left atrial interstitial remodeling in patients with chronic atrial fibrillation undergoing mitral-valve surgery.

Corradi D, Callegari S, Benussi S, Nascimbene S, Pastori P, Calvi S, Maestri R, Astorri E, Pappone C, Alfieri O.

Virchows Arch. 2004 Nov;445(5):498-505. Epub 2004 Jun 19.

Cardiac contractility modulation by non-excitatory electrical currents. The new frontier for electrical therapy of heart failure.

Augello G, Santinelli V, Vicedomini G, Mazzone P, Gulletta S, Maggi F, Mika Y, Chierchia G, Pappone C.

Ital Heart J. 2004 Jun;5 Suppl 6:68S-75S. Review.

Atrio-esophageal fistula as a complication of percutaneous transcatheter ablation of atrial fibrillation.

Pappone C, Oral H, Santinelli V, Vicedomini G, Lang CC, Manguso F, Torracca L, Benussi S, Alfieri O, Hong R, Lau W, Hirata K, Shikuma N, Hall B, Morady F.

Circulation. 2004 Jun 8;109(22):2724-6. Epub 2004 May 24.

[Concomitant treatment of atrial fibrillation in open-heart surgery patients: late rhythm and functional results].

Nascimbene S, Benussi S, Calvi S, Agricola E, La Canna G, Pappone C, Alfieri O.

Ital Heart J Suppl. 2004 Mar;5(3):199-204. Italian.

First human chronic experience with cardiac contractility modulation by nonexcitatory electrical currents for treating systolic heart failure: mid-term safety and efficacy results from a multicenter study.

Pappone C, Augello G, Rosanio S, Vicedomini G, Santinelli V, Romano M, Agricola E, Maggi F, Buchmayr G, Moretti G, Mika Y, Ben-Haim SA, Wolzt M, Stix G, Schmidinger H.

J Cardiovasc Electrophysiol. 2004 Apr;15(4):418-27.

Pulmonary vein denervation enhances long-term benefit after circumferential ablation for paroxysmal atrial fibrillation.

Pappone C, Santinelli V, Manguso F, Vicedomini G, Gugliotta F, Augello G, Mazzone P, Tortoriello V, Landoni G, Zangrillo A, Lang C, Tomita T, Mesas C, Mastella E, Alfieri O.

Circulation. 2004 Jan 27;109(3):327-34. Epub 2004 Jan 5.

Radiofrequency catheter ablation in drug refractory maternal supraventricular tachycardias in advanced pregnancy.

Bombelli F, Lagona F, Salvati A, Catalfamo L, Ferrari AG, Pappone C.

Obstet Gynecol. 2003 Nov;102(5 Pt 2):1171-3.

A randomized study of prophylactic catheter ablation in asymptomatic patients with the Wolff-Parkinson-White syndrome.

Pappone C, Santinelli V, Manguso F, Augello G, Santinelli O, Vicedomini G, Gulletta S, Mazzone P, Tortoriello V, Pappone A, Dicandia C, Rosanio S.

N Engl J Med. 2003 Nov 6;349(19):1803-11.

Origin of atrial fibrillation from the pulmonary veins in a mitral patient.

Melo JQ, Benussi S, Tortoriello W, Santinelli V, Calvi S, Nascimbene S, Pappone C, Alfieri O.

J Thorac Cardiovasc Surg. 2003 Sep;126(3):914-6. No abstract available.

Mortality, morbidity, and quality of life after circumferential pulmonary vein ablation for atrial fibrillation: outcomes from a controlled nonrandomized long-term study.

Pappone C, Rosanio S, Augello G, Gallus G, Vicedomini G, Mazzone P, Gulletta S, Gugliotta F, Pappone A, Santinelli V, Tortoriello V, Sala S, Zangrillo A, Crescenzi G, Benussi S, Alfieri O.

J Am Coll Cardiol. 2003 Jul 16;42(2):185-97.

Heart failure. The pacing therapy.

Pappone C, Santinelli V.

Minerva Cardioangiol. 2003 Apr;51(2):179-84. Review.

Combining electrical therapies for advanced heart failure: the Milan experience with biventricular pacing-defibrillation backup combination for primary prevention of sudden cardiac death.

Pappone C, Vicedomini G, Augello G, Mazzone P, Nardi S, Rosanio S.

Am J Cardiol. 2003 May 8;91(9A):74F-80F. Review.

Sudden death due to atrial fibrillation in hypertrophic cardiomyopathy: a predictable event in a young patient.

Favale S, Pappone C, Nacci F, Fino F, Resta F, Dicandia CD.

Pacing Clin Electrophysiol. 2003 Feb;26(2 Pt 1):637-9.

Evolution of non-pharmacological curative therapy for atrial fibrillation. Where do we stand today?

Pappone C, Rosanio S.

Int J Cardiol. 2003 Apr;88(2-3):135-42. Review.

Pulmonary vein stenosis after catheter ablation for atrial fibrillation.

Pappone C.

J Cardiovasc Electrophysiol. 2003 Feb;14(2):165-7. No abstract available.

Advances for treating in-hospital cardiac arrest: safety and effectiveness of a new automatic external cardioverter-defibrillator.

Martínez-Rubio A, Kanaan N, Borggrefe M, Block M, Mäkijärvi M, Fedele F, Pappone C, Haverkamp W, Merino JL, Esquivias GB, Cinca J; European Powerheart Investigators.

J Am Coll Cardiol. 2003 Feb 19;41(4):627-32.

Usefulness of invasive electrophysiologic testing to stratify the risk of arrhythmic events in asymptomatic patients with Wolff-Parkinson-White pattern: results from a large prospective long-term follow-up study.

Pappone C, Santinelli V, Rosanio S, Vicedomini G, Nardi S, Pappone A, Tortoriello V, Manguso F, Mazzone P, Gulletta S, Oreto G, Alfieri O.

J Am Coll Cardiol. 2003 Jan 15;41(2):239-44.

[Electrophysiological bases of atrial fibrillation].

Oreto G, Pappone C.

Cardiologia. 1999 Dec;44 Suppl 1(Pt 2):889-92. Review. Italian. No abstract available.

Cardiac contractility modulation by electric currents applied during the refractory period in patients with heart failure secondary to ischemic or idiopathic dilated cardiomyopathy.

Pappone C, Rosanio S, Burkhoff D, Mika Y, Vicedomini G, Augello G, Shemer I, Prutchi D, Haddad W, Aviv R, Snir Y, Kronzon I, Alfieri O, Ben-Haim SA.

Am J Cardiol. 2002 Dec 15;90(12):1307-13.

Surgical ablation of atrial fibrillation using the epicardial radiofrequency approach: mid-term results and risk analysis.

Benussi S, Nascimbene S, Agricola E, Calori G, Calvi S, Caldarola A, Oppizzi M, Casati V, Pappone C, Alfieri O.

Ann Thorac Surg. 2002 Oct;74(4):1050-6; discussion 1057.

Atrial fibrillation–a curable condition?

Pappone C.

Eur Heart J. 2002 Apr;23(7):514-7. No abstract available.

Natural history of Brugada syndrome: insights for risk stratification and management.

Priori SG, Napolitano C, Gasparini M, Pappone C, Della Bella P, Giordano U, Bloise R, Giustetto C, De Nardis R, Grillo M, Ronchetti E, Faggiano G, Nastoli J.

Circulation. 2002 Mar 19;105(11):1342-7.

Pulmonary vein isolation by circumferential radiofrequency lesions in atrial fibrillation. From substrate to clinical outcome.

Pappone C, Santinelli V.

Ann Ist Super Sanita. 2001;37(3):401-7.

QRS complex voltage changes associated with supraventricular tachycardia.

Oreto G, Luzza F, Badessa F, Calabrò MP, Mazzone P, Carerj S, Saporito F, Pappone C.

J Cardiovasc Electrophysiol. 2001 Dec;12(12):1358-62.

Atrial electroanatomic remodeling after circumferential radiofrequency pulmonary vein ablation: efficacy of an anatomic approach in a large cohort of patients with atrial fibrillation.

Pappone C, Oreto G, Rosanio S, Vicedomini G, Tocchi M, Gugliotta F, Salvati A, Dicandia C, Calabrò MP, Mazzone P, Ficarra E, Di Gioia C, Gulletta S, Nardi S, Santinelli V, Benussi S, Alfieri O.

Circulation. 2001 Nov 20;104(21):2539-44.

[Prospects of the treatment of atrial fibrillation. Circumferential radiofrequency ablation of pulmonary vein ostia].

Pappone C, Rosanio S, Oreto G, Tocchi M, Gugliotta F, Salvati A, Dicandia C, Mazzone P, Santinelli V, Gulletta S, Vicedomini G.

Recenti Prog Med. 2001 Sep;92(9):508-12. Review. Italian.

Fibroma of the left ventricle in a patient with Sotos syndrome.

Marcì M, Ziino O, D’Angelo P, Miranda G, Pappone C, Battaglia A.

Echocardiography. 2001 Feb;18(2):171-3.

[Epicardial ablation of atrial fibrillation during heart valve surgery].

Benussi S, Nascimbene S, Agricola E, Caldarola A, Casati V, La Canna G, Pappone C, Alfieri O.

Ital Heart J Suppl. 2001 Apr;2(4):396-401. Italian.

Electrical modulation of cardiac contractility: clinical aspects in congestive heart failure.

Pappone C, Vicedomini G, Salvati A, Meloni C, Haddad W, Aviv R, Mika Y, Darvish N, Kimchy Y, Shemer I, Snir Y, Pruchi D, Ben-Haim SA, Kronzon I.

Heart Fail Rev. 2001 Jan;6(1):55-60. Review.

Acute electrophysiologic effect of estradiol 17beta in menopausal women.

Rosano GM, Leonardo F, Dicandia C, Sheiban I, Pagnotta P, Pappone C, Chierchia SL.

Am J Cardiol. 2000 Dec 15;86(12):1385-7, A5-6.

Circumferential radiofrequency ablation of pulmonary vein ostia: A new anatomic approach for curing atrial fibrillation.

Pappone C, Rosanio S, Oreto G, Tocchi M, Gugliotta F, Vicedomini G, Salvati A, Dicandia C, Mazzone P, Santinelli V, Gulletta S, Chierchia S.

Circulation. 2000 Nov 21;102(21):2619-28.

Clinical and genetic heterogeneity of right bundle branch block and ST-segment elevation syndrome: A prospective evaluation of 52 families.

Priori SG, Napolitano C, Gasparini M, Pappone C, Della Bella P, Brignole M, Giordano U, Giovannini T, Menozzi C, Bloise R, Crotti L, Terreni L, Schwartz PJ.

Circulation. 2000 Nov 14;102(20):2509-15.

Cardiac pacing in heart failure patients with left bundle branch block: impact of pacing site for optimizing left ventricular resynchronization.

Pappone C, Rosanio S, Oreto G, Tocchi M, Gulletta S, Salvati A, Dicandia C, Santinelli V, Mazzone P, Veglia F, Ding J, Sallusti L, Spinelli J, Vicedomini G.

Ital Heart J. 2000 Jul;1(7):464-9.

A simple way to treat chronic atrial fibrillation during mitral valve surgery: the epicardial radiofrequency approach.

Benussi S, Pappone C, Nascimbene S, Oreto G, Caldarola A, Stefano PL, Casati V, Alfieri O.

Eur J Cardiothorac Surg. 2000 May;17(5):524-9.

Low energy transvenous atrial defibrillation. When and how to use it.

Pappone C.

Ital Heart J. 2000 Feb;1(2):143-5. No abstract available.

Paroxysmal supraventricular tachycardia caused by 1:2 atrioventricular conduction in the presence of dual atrioventricular nodal pathways.

Fraticelli A, Saccomanno G, Pappone C, Oreto G.

J Electrocardiol. 1999 Oct;32(4):347-54.

Catheter ablation of paroxysmal atrial fibrillation using a 3D mapping system.

Pappone C, Oreto G, Lamberti F, Vicedomini G, Loricchio ML, Shpun S, Rillo M, Calabrò MP, Conversano A, Ben-Haim SA, Cappato R, Chierchia S.

Circulation. 1999 Sep 14;100(11):1203-8.

[The ablation of chronic atrial fibrillation during mitral surgery: a realistic prospect].

Alfieri O, Benussi S, Nascimbene S, Pappone C.

G Ital Cardiol. 1998 Nov;28(11):1317-21. Review. Italian. No abstract available.

Atrial fibrillation in elite athletes.

Furlanello F, Bertoldi A, Dallago M, Galassi A, Fernando F, Biffi A, Mazzone P, Pappone C, Chierchia S.

J Cardiovasc Electrophysiol. 1998 Aug;9(8 Suppl):S63-8.

Cardiac arrest and sudden death in competitive athletes with arrhythmogenic right ventricular dysplasia.

Furlanello F, Bertoldi A, Dallago M, Furlanello C, Fernando F, Inama G, Pappone C, Chierchia S.

Pacing Clin Electrophysiol. 1998 Jan;21(1 Pt 2):331-5.

Inappropriate sinus tachycardia after radiofrequency ablation of para-Hisian accessory pathways.

Pappone C, Stabile G, Oreto G, De Simone A, Rillo M, Mazzone P, Cappato R, Chierchia S.

J Cardiovasc Electrophysiol. 1997 Dec;8(12):1357-65.

Palpitations: what is the mechanism, and when should we treat them?

Rosano GM, Rillo M, Leonardo F, Pappone C, Chierchia SL.

Int J Fertil Womens Med. 1997 Mar-Apr;42(2):94-100. Review.

[The physical and chemical principles of radiofrequency catheter ablation in arrhythmias].

Stabile G, Pappone C, Solimene F, Senatore G, De Simone A, Marrazzo N, Mazzone P, Chiariello M.

Cardiologia. 1996 Nov;41(11):1053-9. Review. Italian. No abstract available.

Role of catheter-induced mechanical trauma in localization of target sites of radiofrequency ablation in automatic atrial tachycardia.

Pappone C, Stabile G, De Simone A, Senatore G, Turco P, Damiano M, Iorio D, Spampinato N, Chiariello M.

J Am Coll Cardiol. 1996 Apr;27(5):1090-7.

Effects of dual-chamber pacing in hypertrophic cardiomyopathy on left ventricular outflow tract obstruction and on diastolic function.

Betocchi S, Losi MA, Piscione F, Boccalatte M, Pace L, Golino P, Perrone-Filardi P, Briguori C, Franculli F, Pappone C, Salvatore M, Chiariello M.

Am J Cardiol. 1996 Mar 1;77(7):498-502.

[Radiofrequency catheter ablation of atrial tachycardia: technique, results and follow-up].

Pappone C, Stabile G, De Simone A, Senatore G, Turco P, Marrazzo N, Mazzone P, Santomauro M, Chiariello M.

G Ital Cardiol. 1996 Jan;26(1):5-19. Italian.

[Atrioventricular conduction before and after the radiofrequency catheter ablation of a nodal reentry tachycardia circuit].

Pappone C, De Simone A, Stabile G, Senatore G, Lamberti F, Solimene F, Turco P, Santomauro M, Chiariello M.

Cardiologia. 1994 Aug;39(8):565-75. Italian.

[Ablation of paroxysmal tachycardia in Wolff-Parkinson-White syndrome].

Pappone C, Lamberti F, Santomauro M, Stabile G, De Simone A, Turco P, Pannain S, Loricchio ML, Rotunno R, Chiariello M.

Cardiologia. 1993 Dec;38(12 Suppl 1):189-97. Italian.

[A methodological approach to the transcatheter radiofrequency ablation of anomalous Kent-type pathways].

Pappone C, Lamberti F, Santomauro M, Stabile G, De Simone A, Franciosa P, Senatore G, Loricchio ML, Chiariello M.

Cardiologia. 1993 Oct;38(10):651-60. Italian.

Clinical experience with the transvenous Medtronic Pacer Cardioverter Defibrillator (PCD) System.

Golino A, Pappone C, Panza A, Santomauro M, Iorio D, De Amicis V, Chiariello M, Spampinato N.

Tex Heart Inst J. 1993;20(4):264-70.

Pacemaker malfunction due to subcutaneous emphysema–a case report.

Santomauro M, Ferraro S, Maddalena G, Fazio S, Covino E, Pappone C, Spampinato N, Chiariello M.

Angiology. 1992 Oct;43(10):873-6.

Diagnosis of coronary artery disease with Tc 99m-methoxy isobutyl isonitrile and transesophageal pacing.

Santomauro M, Cuocolo A, Celentano L, Ferraro S, Pace L, Pappone C, Maddalena G, Salvatore M, Chiariello M.

Angiology. 1992 Oct;43(10):818-25.

Follow-up of a respiratory rate modulated pacemaker.

Santomauro M, Fazio S, Ferraro S, Maddalena G, Papaccioli G, Pappone C, Saccà L, Chiariello M.

Pacing Clin Electrophysiol. 1992 Jan;15(1):17-21.

Fourier analysis in patients with different pacing modes.

Santomauro M, Fazio S, Ferraro S, Maddalena G, Papaccioli G, Pappone C, Betocchi S, Chiariello M.

Pacing Clin Electrophysiol. 1991 Sep;14(9):1351-8.

[Anaerobic threshold in the evaluation of heart function in patients with rate-responsive pacemaker].

Santomauro M, Romano M, Pappone C, Ferraro S, Fazio S, Maddalena G, Damiano M, Chiariello M.

Cardiologia. 1991 Aug;36(8):603-9. Italian.

Studi clinici attualmente in atto registrati sul sito // Current Clinical Trials Registred at www.clinicaltrials.gov

(Registered Ongoing Studies, N=5)

Study 1:

Title: Arrhythmogenic Substrate in Primary Cardiomyopathies
Status: Recruiting
Study Results: No Results Available
Conditions: Primary Cardiomyopathy
Interventions: Other: ablation
Locations: IRCCS Policlinico S. Donato, San Donato Milanese, Milano, Italy
URL: https://ClinicalTrials.gov/show/NCT03304847

Study 2:

Title: Epicardial Ablation in Brugada Syndrome to Prevent Sudden Death
Status: Recruiting
Study Results: No Results Available
Conditions: Ventricular Arrhythmias and Cardiac Arrest
Interventions: Other: ablation plus ICD
Locations: IRCCS Policlinico S. Donato, San Donato Milanese, Milano, Italy
URL: https://ClinicalTrials.gov/show/NCT03294278

Study 3:

Title: Epicardial Ablation in Brugada Syndrome. An Extension Study of 500

BrS.Patients
Status: Recruiting
Study Results: No Results Available
Conditions: ECG Brugada Pattern
Interventions: Procedure: Ablation
Location: IRCCS Policlinico S. Donato, San Donato Milanese, Milano, Italy
URL: https://ClinicalTrials.gov/show/NCT03106701

Study 4:

Title: Right Ventricle Morphology and Hemodynamics in BrS
Status: Recruiting
Study Results: No Results Available
Conditions: Brugada Syndrome
Interventions: Drug: Ajmaline 17-(Chloroacetate) Monohydrochloride
Locations: IRCCS Policlinico S. Donato, San Donato Milanese, Milano, Italy
URL: https://ClinicalTrials.gov/show/NCT03524079

Study 5:

Title: Simultaneous or Sequential Multipoint Pacing
Status: Recruiting
Study Results: No Results Available
Conditions: Cardiac Resynchronization Therapy
Interventions: Device: CRT
Locations: IRCCS Policlinico S. Donato, San Donato Milanese, Milano, Italy
URL: https://ClinicalTrials.gov/show/NCT03301363

HEART RHYTHM SOCIETY

AMERICAN COLLEGE OF CARDIOLOGY

EUROPEAN SOCIETY OF CARDIOLOGY

AMERICAN HEART ASSOCIATION

NATIONAL HEART BLOOD AND LUNG INSTITUTE

PUBMED

MAYO CLINIC

I.R.C.C.S. POLICLINICO SAN DONATO

SIC https://www.sicardiologia.it/

ANMCO http://www.anmco.it/

AIAC http://aiac.it/

ISE http://www.electrocardiology.org/

ISHNE https://www.ishne.org/

AIFA https://aifa.gov.it/

Sanità Regione Lombardia https://www.regione.lombardia.it/wps/portal/istituzionale/HP/servizi-e-informazioni/cittadini/salute-e-prevenzione

Clinical Trial: https://clinicaltrials.gov/

Credible Meds https://crediblemeds.org/

Medsafe https://www.medsafe.govt.nz/profs/PUArticles/DrugInducedQTProlongation.htm

Orphanet: https://www.orpha.net/consor/cgi-bin/index.php

ISHNE ECG University https://ecguniversity.org/

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